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六君子汤治疗肿瘤相关性厌食症的研究进展。

Research Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia.

机构信息

School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.

出版信息

Drug Des Devel Ther. 2022 Jun 7;16:1731-1741. doi: 10.2147/DDDT.S365292. eCollection 2022.

DOI:10.2147/DDDT.S365292
PMID:35698654
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9188393/
Abstract

Tumor-associated anorexia, mainly including cancerous anorexia and chemotherapy-induced anorexia, severely reduces the life quality of cancer patients but lacks of effective control until now. Liujunzi decoction (LJZD), a classical tonifying formula in traditional Chinese medicine, has promising effect in preventing and treating many kinds of anorexia. A growing number of evidence showed that LJZD is able to improve tumor-associated anorexia. Up to March 2022, a total of 58 articles studying LJZD or Rikkunshito (the name of LJZD in Japanese herbal medicine) in the treatment of tumor-associated anorexia are searched out in PubMed. This paper summarizes the effect of LJZD in ameliorating tumor-associated anorexia, in order to provide a theoretical basis for the clinical application of LJZD in treating tumor-associated anorexia, laying foundation for further research.

摘要

肿瘤相关性厌食症，主要包括癌性厌食症和化疗相关性厌食症，严重降低了癌症患者的生活质量，但至今缺乏有效的控制手段。六君子汤（LJZD）是一种经典的中药滋补方，在预防和治疗多种厌食症方面具有良好的效果。越来越多的证据表明，LJZD 能够改善肿瘤相关性厌食症。截至 2022 年 3 月，在 PubMed 上共检索到 58 篇关于 LJZD 或六君子汤（LJZD 的日本草药名称）治疗肿瘤相关性厌食症的研究文章。本文总结了 LJZD 改善肿瘤相关性厌食症的作用，以期为 LJZD 治疗肿瘤相关性厌食症的临床应用提供理论依据，为进一步研究奠定基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/204fd61862f5/DDDT-16-1731-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/7f10ac89b9ea/DDDT-16-1731-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/3810fbc6652e/DDDT-16-1731-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/204fd61862f5/DDDT-16-1731-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/7f10ac89b9ea/DDDT-16-1731-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/3810fbc6652e/DDDT-16-1731-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e657/9188393/204fd61862f5/DDDT-16-1731-g0003.jpg

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Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing.单细胞 RNA 测序发现胰腺癌作用下下丘脑基因网络的关键变化。
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Ghrelin Enhancer, the Latest Evidence of Rikkunshito.
基于网络药理学和分子对接技术探讨六君子汤治疗乳腺癌的潜在作用机制。
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Front Nutr. 2021 Dec 9;8:761631. doi: 10.3389/fnut.2021.761631. eCollection 2021.
4
Liujunzi Decoction ameliorated cisplatin-induced anorexia by inhibiting the JAK-STAT signaling pathway and coordinating anorexigenic and orexigenic neuropeptides in rats.六君子汤通过抑制 JAK-STAT 信号通路和协调厌食性和食欲性神经肽来改善顺铂诱导的大鼠厌食症。
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[Pharmacological profile and clinical efficacy of anamorelin HCl (ADLUMIZTablets), the first orally available drug for cancer cachexia with ghrelin-like action in Japan].[盐酸阿那莫林（ADLUMIZ 片剂）的药理特性及临床疗效，日本首个具有胃饥饿素样作用的口服癌症恶病质治疗药物]
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