Damdinsuren Erdenesuvd, Naidansuren Purevjargal, Gochoo Mendsaikhan, Choi Bum-Chae, Choi Min-Youp, Baldandorj Bolorchimeg
Department of Obstetrics and Gynecology, Mongolian National University of Medical Sciences School of Medicine, Ulaanbaatar, Mongolia.
Mon-CL Fertility Center, Ulaanbaatar, Mongolia.
Clin Exp Reprod Med. 2022 Jun;49(2):101-109. doi: 10.5653/cerm.2021.05099. Epub 2022 Apr 8.
Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men.
A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined.
Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%.
The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.
Y染色体微缺失是继克兰费尔特综合征后男性不育的第二大常见遗传原因。本研究的目的是确定不育蒙古族男性中Y染色体微缺失的模式。
2017年2月至2018年12月对75名不育男性进行了描述性研究。通过聚合酶链反应鉴定Y染色体微缺失。检查精液参数、激素水平和睾丸活检样本。
75名不育男性中，鉴定出2例Y染色体微缺失。第一例为AZFa完全缺失，另一例为AZFc部分缺失。本研究发现不育蒙古族男性中Y染色体微缺失的比例为2.66%。
这些发现可应用于体外受精和辅助生殖技术，我们的结果将有助于临床医生改善对不育蒙古族夫妇的治疗管理。
