Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
958 Hospital of PLA Army, Chongqing, China.
Pharmacogenomics. 2022 Jul;23(10):575-583. doi: 10.2217/pgs-2022-0052. Epub 2022 Jun 14.
To investigate whether the gene affects risperidone treatment outcomes in the Chinese population. A total of 148 unrelated inpatients who received risperidone for six weeks were enrolled. The selected single nucleotide polymorphisms (SNPs; rs2088885, rs7627954 and rs13065441) were genotyped using the MassARRAY SNP IPLEX platform. The analysis showed that one novel SNP of , rs7627954, had a significant association with the response to risperidone (χ = 4.472; p = 0.034). This work also identified rs2088885 as significantly associated with risperidone response (χ = 5.257; p = 0.022). The result revealed that the rs2088885-rs7627954 C-T haplotype was more prevalent in good responders than in poor responders (p = 0.0278). This study revealed that the rs2088885 and rs7627954 SNPs of are associated with risperidone treatment response.
为了探究该基因是否会影响中国人对利培酮的治疗效果，我们共纳入了 148 名接受利培酮治疗六周的非亲缘住院患者。使用 MassARRAY SNP IPLEX 平台对所选的三个单核苷酸多态性(rs2088885、rs7627954 和 rs13065441)进行基因分型。分析表明，基因的一个新的单核苷酸多态性(rs7627954)与利培酮的疗效显著相关(χ2=4.472;p=0.034)。此外，我们还发现 rs2088885 与利培酮的疗效显著相关(χ2=5.257;p=0.022)。结果显示，rs2088885-rs7627954 的 C-T 单倍型在疗效良好的患者中比疗效差的患者更为常见(p=0.0278)。这项研究表明，基因的 rs2088885 和 rs7627954 单核苷酸多态性与利培酮的治疗反应有关。
