The influence of gene polymorphisms on risperidone response in a Chinese Han population.

To investigate whether the gene affects risperidone treatment outcomes in the Chinese population. A total of 148 unrelated inpatients who received risperidone for six weeks were enrolled. The selected single nucleotide polymorphisms (SNPs; rs2088885, rs7627954 and rs13065441) were genotyped using the MassARRAY SNP IPLEX platform. The analysis showed that one novel SNP of , rs7627954, had a significant association with the response to risperidone (χ = 4.472; p = 0.034). This work also identified rs2088885 as significantly associated with risperidone response (χ = 5.257; p = 0.022). The result revealed that the rs2088885-rs7627954 C-T haplotype was more prevalent in good responders than in poor responders (p = 0.0278). This study revealed that the rs2088885 and rs7627954 SNPs of are associated with risperidone treatment response.