白塞病中的缺血性心脏病：一项系统评价与荟萃分析。
Ischaemic heart disease in Behçet's syndrome: a systematic review and meta-analysis.
作者信息
Yang Yang, Yu Ye, Sun Chuanyin, Jiang Mengdi, Lin Jin
机构信息
Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
出版信息
Clin Exp Rheumatol. 2022 Sep;40(8):1497-1503. doi: 10.55563/clinexprheumatol/1shqmz. Epub 2022 Jun 6.
OBJECTIVES
Behçet's syndrome (BS) has been reported with cardiovascular involvement. It's still unclear that BS is associated with the increased risk of ischaemic heart disease (IHD). We aimed to conduct a meta-analysis concerning the incidence of IHD in BS and identify the relationship between IHD and BS.
METHODS
We performed a comprehensive literature search based on PubMed and Embase databases up to 7 July, 2021. Incidence of IHD was calculated by metaproportion. Pooled risk ratio and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird.
RESULTS
Four studies with 9237 patients with IHD in BS and 40353 controls were identified and included in our meta-analysis. The pooled risk ratio of IHD in patients with BS was 1.30 and achieved statistical significance (95% CI 1.04-1.64). The statistical heterogeneity was low with an I2 of 39% (p=0.18).
CONCLUSIONS
In this meta-analysis the presence of BS was associated with an increased risk of IHD. Prospective researches should be done to determine the pathophysiological and prognostic implications of increased IHD in BS.
目的
已有报告称白塞病（BS）会累及心血管系统。白塞病是否与缺血性心脏病（IHD）风险增加相关仍不明确。我们旨在对白塞病中缺血性心脏病的发病率进行荟萃分析，并确定缺血性心脏病与白塞病之间的关系。
方法
我们基于PubMed和Embase数据库进行了全面的文献检索，检索截至2021年7月7日。缺血性心脏病的发病率通过元比例计算。采用DerSimonian和Laird的随机效应、通用逆方差法计算合并风险比和95%置信区间（CI）。
结果
我们确定了四项研究，其中包括9237例白塞病合并缺血性心脏病患者和40353例对照，并将其纳入我们的荟萃分析。白塞病患者缺血性心脏病的合并风险比为1.30，具有统计学意义（95%CI 1.04 - 1.64）。统计异质性较低，I²为39%（p = 0.18）。
结论
在这项荟萃分析中，白塞病与缺血性心脏病风险增加相关。应开展前瞻性研究以确定白塞病中缺血性心脏病增加的病理生理和预后意义。
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