Speech-Language Pathology Department, Universidade Federal de São Paulo - UNIFESP, Brazil.
Speech-Language Pathology Course, Universidade de Brasília - UnB, Distrito Federal, Brazil.
Am J Speech Lang Pathol. 2022 Jul 12;31(4):1611-1620. doi: 10.1044/2022_AJSLP-21-00381. Epub 2022 Jun 14.
The purpose of this study is to analyze the effectiveness of the Therapy Program for Management of Chronic Cough (TMCC) in laryngeal sensations and symptoms related to the cough in individuals with chronic refractory cough (CRC).
This research is a randomized double-blind clinical trial (Register Number: RBR-4m6x29). Eleven participants were allocated to two groups by parallel randomization: The Experimental Group-consisting of six individuals who underwent the TMCC; and the Control Group-consisting of five individuals who underwent the Comprehensive Vocal Rehabilitation Program (CVRP). Two primary outcomes were analyzed: self-perception of laryngeal sensations (Newcastle Laryngeal Hypersensitivity Questionnaire [LHQ-Br]) and self-perception of symptoms of upper airway-related cough (Cough Severity Index [CSI-Br]). The two-way repeated-measures analysis of variance was used to compare the evaluation moments and intervention groups. For multiple comparisons, the Tukey test with Bonferroni correction was used. To evaluate the effect size, eta partial square was used.
There was no difference between groups for any outcomes analyzed. There was a statistically significant difference with a large effect size for the moment factor in all outcomes. A statistically significant difference was observed with a large effect size for the interaction effect between group and moment for LHQ-Br total and CSI-Br psychological and functional.
The TMCC and CVRP were effective for the rehabilitation of CRC, considering the viewpoint of the subject. The TMCC improved laryngeal sensations and psychological and functional symptoms, while CVRP was relevant to improve psychological and functional symptoms in individuals with CRC.
本研究旨在分析慢性咳嗽管理治疗方案（TMCC）对慢性难治性咳嗽（CRC）患者咳嗽相关喉感觉和症状的疗效。
这是一项随机双盲临床试验（注册号：RBR-4m6x29）。通过平行随机化将 11 名参与者分为两组：实验组——6 名接受 TMCC 的个体；对照组——5 名接受综合嗓音康复方案（CVRP）的个体。分析了两个主要结局：喉感觉的自我感知（纽卡斯尔喉过度敏感问卷 [LHQ-Br]）和上气道相关咳嗽症状的自我感知（咳嗽严重程度指数 [CSI-Br]）。采用双向重复测量方差分析比较评估时刻和干预组。对于多重比较，采用带有 Bonferroni 校正的 Tukey 检验。为了评估效应量，使用 eta 部分平方。
各组在任何结局上均无差异。在所有结局中，时刻因素均存在具有大效应量的统计学显著差异。在 LHQ-Br 总分和 CSI-Br 心理和功能方面，组间和时刻间的交互作用存在统计学显著差异，具有大效应量。
从受试者的角度来看，TMCC 和 CVRP 对 CRC 的康复都是有效的。TMCC 改善了喉感觉和心理及功能症状，而 CVRP 与改善 CRC 个体的心理和功能症状有关。
