Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, India.
Department of Biomedical Engineering, Kalasalingam Academy of Research and Education, Krishnankoil, India.
J Biomol Struct Dyn. 2023 Jul;41(11):5067-5085. doi: 10.1080/07391102.2022.2078412. Epub 2022 Jun 14.
A series of metal complexes containing Phenanthroline scaffold [ML] (L-1,10-Phenanthroline derivative comprises conjugated aromatic core and selenol group); M = Cu(II), Zn(II), Co(II) and Zn(II) ions were designed and synthesised to obtain effective anti-cholinesterase efficiencies of metal chelates. Analytical and spectroscopic studies were used to determine the structural features. An octahedral structure with moderate distortion was attributed to the above metal chelates based on spectroscopic data. The distorted octahedral geometry of copper(II) complex to DNA ( = 4.05 × 10 M) is stronger than that of ethidium bromide (EB) to DNA ( = 3.2 × 10 M), other metal complexes, respectively. The synthesised 1,10-Phenanthroline derivative had the best inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase, with IC values of 0.45 and 3.6 M, respectively, which were lower than the reference molecules. As a result, nitrogen-containing heterocyclic compounds (HL) showed significant inhibitory profiles against the metabolic enzymes. Therefore, we believe that these experimental results may contribute to the development of new drug molecules particularly in the treatment of neurological disorders including glaucoma, Alzheimer's disease (AD) and diabetes. Docking, AChE and BuChE inhibition activities results revealed that ligand may be used for AD. The prepared 1,10-phenanthroline analogue, which has a high selectivity for AChE, may be studied further to find potential candidates for treating early-stage Alzheimer's symptoms.Communicated by Ramaswamy H. Sarma.
一系列含有菲咯啉支架的金属配合物 [ML]（L-1,10-菲咯啉衍生物包含共轭芳香核心和硒醇基团）；M = Cu(II), Zn(II), Co(II) 和 Zn(II) 离子被设计和合成，以获得金属配合物的有效抗胆碱酯酶效率。分析和光谱研究用于确定结构特征。基于光谱数据，归因于上述金属配合物具有中等扭曲的八面体结构。铜(II)配合物与 DNA 的扭曲八面体几何形状（ = 4.05 × 10 M）强于溴化乙锭（EB）与 DNA 的扭曲八面体几何形状（ = 3.2 × 10 M），分别为其他金属配合物。合成的 1,10-菲咯啉衍生物对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶具有最佳的抑制作用，IC 值分别为 0.45 和 3.6 M，低于参考分子。结果表明，含氮杂环化合物（HL）对代谢酶表现出显著的抑制作用。因此，我们认为这些实验结果可能有助于开发新的药物分子，特别是在治疗包括青光眼、阿尔茨海默病（AD）和糖尿病在内的神经紊乱方面。对接、AChE 和 BuChE 抑制活性结果表明配体可能用于 AD。具有高选择性的 AChE 的制备的 1,10-菲咯啉类似物可能进一步研究，以寻找治疗早期阿尔茨海默病症状的潜在候选药物。由 Ramaswamy H. Sarma 交流。
