Centre for Biotechnology, Maharshi Dayanand University, Rohtak, India.
Department of Microbiology, Maharshi Dayanand University, Rohtak, India.
Biotechnol Genet Eng Rev. 2023 Apr;39(1):45-84. doi: 10.1080/02648725.2022.2082157. Epub 2022 Jun 14.
Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ineffectiveness of treatments. Besides, the associated high costs, technical requirements, and cytotoxicity further characterize their limitations. Due to relatively higher presidencies, bioactive peptides with anti-cancer attributes have recently become treatment choices within the therapeutic arsenal. The peptides act as potential anti-cancer agents explicitly targeting tumor cells while being less toxic to normal cells. The anti-cancer peptides are isolated from various natural sources, exhibit high selectivity and high penetration efficiency, and could be quickly restructured. The therapeutic benefits of compatible anti-cancer peptides have contributed to the significant expansion of cancer treatment; albeit, the mechanisms by which bioactive peptides inhibit the proliferation of tumor cells remain unclear. This review will provide a framework for assessing anti-cancer peptides' structural and functional aspects. It shall provide appropriate information on their mode of action to support and strengthen efforts to improve cancer prevention. The article will mention the therapeutic health benefits of anti-cancer peptides. Their importance in clinical studies is elaborated for reducing cancer incidences and developing sustainable treatment models.
人类癌症仍然是全球高死亡率的一个原因。目前用于治疗的常规方法和疗法伴随着中度至重度的副作用。由于治疗无效，它们没有产生治愈效果。此外，相关的高成本、技术要求和细胞毒性进一步限制了它们的应用。由于相对较高的功效，具有抗癌属性的生物活性肽最近已成为治疗选择中的一种治疗方法。这些肽作为潜在的抗癌药物，专门针对肿瘤细胞，而对正常细胞的毒性较小。抗癌肽是从各种天然来源中分离出来的，具有高选择性和高穿透效率，并且可以快速重构。相容的抗癌肽的治疗益处促进了癌症治疗的显著扩展；尽管如此，生物活性肽抑制肿瘤细胞增殖的机制仍不清楚。本综述将为评估抗癌肽的结构和功能方面提供一个框架。它将提供有关其作用机制的适当信息，以支持和加强改善癌症预防的努力。本文将提到抗癌肽的治疗健康益处。为了降低癌症发病率和开发可持续的治疗模式，阐述了它们在临床研究中的重要性。
