Simi M, Leardi S, Tebano M T, Castelli M, Costantini F M, Speranza V
Gut. 1987 Mar;28(3):336-8. doi: 10.1136/gut.28.3.336.
Plasma platelet factor 4 (PF4), secreted by the platelets, is an index of platelet aggregation and thromboembolic risk. The authors assessed PF4 in 20 patients with Crohn's disease (ileitis in 13 patients, ileocolitis in seven) and in 20 healthy volunteers. Disease activity was low (Crohn's Disease Activity Index less than 150) in 11 patients and high in nine. Radioimmunoassay of PF4 using Abbott's Kit was performed on one sample of plasma from each subject (nv less than or equal to 0.324 nmol/ml), (nv less than or equal to 10 ng/ml). A significantly higher concentration of PF4 was found in Crohn's disease patients: 4.625 +/- 1.1 nmol/ml (142.5 +/- 36 ng/ml) than in the control group: 0.189 +/- 0.07 nmol/ml (5.6 +/- 4.8 ng/ml) (Z = 5.396, p less than 0.0001). No correlation was present between PF4 levels and activity, the site of disease, or medical treatment with or without prednisone.
血小板分泌的血浆血小板因子4（PF4）是血小板聚集和血栓栓塞风险的一个指标。作者评估了20例克罗恩病患者（13例为回肠炎，7例为回结肠型肠炎）和20名健康志愿者的PF4水平。11例患者疾病活动度低（克罗恩病活动指数小于150），9例患者疾病活动度高。使用雅培试剂盒对每个受试者的一份血浆样本进行PF4放射免疫测定（正常范围小于或等于0.324纳摩尔/毫升），（正常范围小于或等于10纳克/毫升）。发现克罗恩病患者的PF4浓度显著高于对照组：4.625±1.1纳摩尔/毫升（142.5±36纳克/毫升），而对照组为0.189±0.07纳摩尔/毫升（5.6±4.8纳克/毫升）（Z = 5.396，p < 0.0001）。PF4水平与疾病活动度、疾病部位或是否使用泼尼松治疗均无相关性。
