Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Parkinsonism Relat Disord. 2022 Jul;100:37-40. doi: 10.1016/j.parkreldis.2022.05.025. Epub 2022 Jun 9.
Limited studies have focused on non-motor symptoms (NMS) in patients with Writer's cramp (WC). The current study aimed to examine the frequency of NMS and their association with health-related quality of life (HR-QoL) in patients with WC.
A total of 80 patients with WC and 69 healthy controls (HCs) were enrolled. Motor symptoms was assessed by Burke-Fahn-Marsden dystonia rating scale and NMS was evaluated through several specific scales, including Hamilton depression rating scale-24 items (HDRS-24), Hamilton anxiety rating scale, Epworth sleepiness scale, Pittsburgh sleep quality index, fatigue severity scale (FSS), numerical rating scale for pain, and Montreal cognitive assessment. The HR-QoL was assessed using 36-item short form health survey (SF-36), which can be divided into physical component summary (PCS) and mental component summary (MCS). Multiple linear regression was used to analysis the association between each NMS and HR-QoL.
The patients presented more symptoms of depression, anxiety, poor quality of sleep, excessive daytime sleepiness, and fatigue than the HCs. The most frequent NMS in patients with WC was anxiety (51.25%) and depression (46.25%) symptoms. We found that motor symptoms had no association with HR-QoL. Higher scores of HDRS-24 were associated with lower scores of SF-36 in PCS and MCS. Meantime, higher scores of FSS were significantly associated with lower scores of SF-36 in MCS.
The NMS was prevalent in patients with WC, with frequent anxiety and depression symptoms. Depression symptoms and fatigue had a strongly negative impact on HR-QoL and deserve attention in clinic practice.
已有研究较少关注书写痉挛（WC）患者的非运动症状（NMS）。本研究旨在探讨 WC 患者 NMS 的发生频率及其与健康相关生活质量（HR-QoL）的关系。
共纳入 80 例 WC 患者和 69 例健康对照者（HCs）。采用 Burke-Fahn-Marsden 肌张力障碍评定量表评估运动症状，通过 Hamilton 抑郁量表-24 项（HDRS-24）、Hamilton 焦虑量表、Epworth 嗜睡量表、匹兹堡睡眠质量指数、疲劳严重程度量表（FSS）、疼痛数字评分量表和蒙特利尔认知评估等特定量表评估 NMS。采用 36 项简明健康调查问卷（SF-36）评估 HR-QoL，可分为生理成分综合评分（PCS）和心理成分综合评分（MCS）。采用多元线性回归分析 NMS 与 HR-QoL 之间的关系。
与 HCs 相比，WC 患者表现出更多的抑郁、焦虑、睡眠质量差、日间嗜睡和疲劳症状。WC 患者最常见的 NMS 是焦虑（51.25%）和抑郁（46.25%）症状。我们发现运动症状与 HR-QoL 无关。HDRS-24 评分越高，SF-36 PCS 和 MCS 评分越低。同时，FSS 评分越高，SF-36 MCS 评分越低。
WC 患者 NMS 较为常见，以焦虑和抑郁症状为主。抑郁症状和疲劳对 HR-QoL 有强烈的负面影响，在临床实践中值得关注。
