Novaretti Nathália, Cunha Ana Luiza N, Bezerra Torben C, Pena Pereira Marcio Alexandre, de Oliveira Daniel Sabino, Macruz Brito Manuelina Mariana C, Pimentel Angela V, Brozinga Tamara R, Foss Maria Paula, Tumas Vitor
Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, BR.
Tremor Other Hyperkinet Mov (N Y). 2019 Feb 4;9:596. doi: 10.7916/fhnv-v355. eCollection 2019.
Idiopathic focal dystonia is a motor syndrome associated with dysfunction of basal ganglia circuits. Observations have suggested that many other non-motor symptoms may also be part of the clinical picture. The aim was to assess the prevalence and correlation of non-motor symptoms in patients with common idiopathic focal or segmental dystonia.
In a single-center cross-sectional case-control study, we evaluated the presence of pain, neuropsychiatric symptoms, and sleep alterations in 28 patients with blepharospasm, 28 patients with cervical dystonia, 24 patients with writer's cramp, and 80 control subjects matched for sex, age, and schooling. We obtained clinical and demographic data, and evaluated patients using the Fahn-Marsden Dystonia Rating Scale and other specific scales for dystonia. All subjects completed the following questionnaires: Beck Depression Inventory, Beck Anxiety Inventory, Social Phobia Inventory, Apathy Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Brief Pain Scale, and the World Health Organization Quality of Life brief scale.
The patients presented more symptoms of depression, anxiety, and apathy than the control subjects. They also reported worse quality of sleep and more pain complaints. Patients with blepharospasm were the most symptomatic subgroup. The patients had worse quality of life, and the presence of pain and symptoms of apathy and depression were the main influences for these findings, but not the severity of motor symptoms.
Patients with dystonia, especially those with blepharospasm, showed higher prevalence of symptoms of depression, anxiety, apathy, worse quality of sleep, and pain. These symptoms had a negative impact on their quality of life.
特发性局灶性肌张力障碍是一种与基底神经节回路功能障碍相关的运动综合征。观察表明，许多其他非运动症状也可能是临床表现的一部分。目的是评估常见特发性局灶性或节段性肌张力障碍患者中非运动症状的患病率及相关性。
在一项单中心横断面病例对照研究中，我们评估了28例眼睑痉挛患者、28例颈部肌张力障碍患者、24例书写痉挛患者以及80名在性别、年龄和受教育程度相匹配的对照者中疼痛、神经精神症状和睡眠改变的情况。我们获取了临床和人口统计学数据，并使用法恩-马斯登肌张力障碍评定量表及其他针对肌张力障碍的特定量表对患者进行评估。所有受试者均完成以下问卷：贝克抑郁量表、贝克焦虑量表、社交恐惧症量表、淡漠量表、爱泼华嗜睡量表、匹兹堡睡眠质量指数、简明疼痛量表以及世界卫生组织生活质量简表。
与对照者相比，患者出现更多的抑郁、焦虑和淡漠症状。他们还报告睡眠质量更差且疼痛主诉更多。眼睑痉挛患者是症状最明显的亚组。患者的生活质量较差，疼痛、淡漠和抑郁症状的存在是这些结果的主要影响因素，而非运动症状的严重程度。
肌张力障碍患者，尤其是眼睑痉挛患者，抑郁、焦虑、淡漠症状的患病率更高，睡眠质量更差且疼痛更多。这些症状对他们的生活质量产生了负面影响。
