Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK; Department of Psychiatry, University of Oxford, Oxford, UK.
Department of Psychiatry, University of Oxford, Oxford, UK.
Sleep Med Rev. 2022 Aug;64:101647. doi: 10.1016/j.smrv.2022.101647. Epub 2022 May 26.
Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. The aim of this systematic review and meta-analysis is to assess the clinical effects of sleep deprivation in comparison to any other intervention for the acute and long-term treatment of mood disorders. We searched electronic databases and trial registries (last update: 16th October 2021) for published and unpublished randomised controlled trials recruiting participants with a major depressive episode in unipolar or bipolar affective disorder. The clinical outcomes of interest were the reduction in depressive symptoms at different timepoints and the number of participants experiencing at least one side effect. Overall, 29 trials (1246 participants) were included. We did not find any difference in change in symptoms or all-cause discontinuation between interventions including SD compared to a control of the same intervention except without SD. In the included studies there were no available data for adverse events. Using the most methodologically rigorous approach, we did not find evidence that the addition of sleep deprivation to treatment packages leads to enhanced depressive outcomes.
睡眠剥夺，单独或与药物治疗联合使用，并作为时间疗法的一部分，对于患有重性抑郁发作的人可能有用，然而，证据基础仍然存在矛盾。本系统评价和荟萃分析的目的是评估睡眠剥夺与任何其他干预措施在急性和长期治疗心境障碍方面的临床效果。我们检索了电子数据库和试验登记处（最后更新日期：2021 年 10 月 16 日），以寻找招募单相或双相情感障碍重性抑郁发作患者的已发表和未发表的随机对照试验。我们关注的临床结局是不同时间点抑郁症状的减轻以及至少有一名参与者出现至少一种副作用的人数。总的来说，纳入了 29 项试验（1246 名参与者）。我们没有发现包括睡眠剥夺在内的干预措施与相同干预措施的对照组相比，在症状变化或所有原因停药方面有任何差异。在纳入的研究中，没有关于不良事件的可用数据。使用最具方法学严谨性的方法，我们没有发现证据表明将睡眠剥夺添加到治疗方案中会导致抑郁结局的改善。
