Sarcoma Unit, Department of Surgery, University Medical Center Mannheim, Mannheim, Germany.
National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.
Oncol Res Treat. 2022;45(11):660-669. doi: 10.1159/000525288. Epub 2022 Jun 14.
Health-related quality of life (HRQoL) is crucial for shared decision-making. The "Patient-Reported Outcome measures in Sarcoma" (PROSa) study evaluated HRQoL in general. We evaluated the transferability of PROSa data to clinical practice for the subgroup of retroperitoneal sarcoma (RPS).
To obtain a PROSa-RPS cohort, we excluded patients with bone sarcomas and gastrointestinal stromal tumors from the complete PROSa cohort (n = 1,113), limited tumor localization to trunk and retroperitoneum, and excluded patients with metastases. We evaluated the HRQoL data of the resulting 76 patients and compared their clinical data to those of the Transatlantic Autralasian Retroperitoneal Sarcoma Working Group (TARPS-WG, n = 1,007).
Confidence intervals for patient sex, histological subtype (LPS vs. non-LPS), grading (G1 vs. G2/3), surgical margins (R2 vs. no R2), and perioperative chemo- and radiotherapy (yes vs. no) were overlapping in both cohorts. EORTC QLQ-C30 from RPS-PROSa patients demonstrated that two-thirds had clinically relevant restrictions in physical functioning. Two-thirds reported dyspnea, followed by fatigue and pain.
Clinical data from RPS-PROSa patients are comparable to those of an RPS reference cohort from expert centers. We believe that HRQoL data of RPS patients extracted from PROSa are transferable to clinical practice.
健康相关生活质量（HRQoL）对于共同决策至关重要。“肉瘤患者报告结局测量”（PROSa）研究总体上评估了 HRQoL。我们评估了 PROSa 数据对包括腹膜后肉瘤（RPS）亚组在内的临床实践的可转移性。
为了获得 PROSa-RPS 队列，我们从完整的 PROSa 队列（n=1113）中排除了骨肉瘤和胃肠道间质瘤患者，将肿瘤局限于躯干和腹膜后，排除了转移患者。我们评估了由此产生的 76 名患者的 HRQoL 数据，并将其临床数据与跨大西洋澳大拉西亚腹膜后肉瘤工作组（TARPS-WG，n=1007）的临床数据进行了比较。
两组患者的性别、组织学亚型（低级别软组织肉瘤[LPS]与非 LPS）、分级（G1 与 G2/3）、手术切缘（R2 与无 R2）和围手术期化疗和放疗（是与否）的置信区间重叠。来自 RPS-PROSa 患者的 EORTC QLQ-C30 表明，三分之二的患者在身体功能方面存在临床相关的限制。三分之二的患者报告呼吸困难，其次是疲劳和疼痛。
RPS-PROSa 患者的临床数据与专家中心的 RPS 参考队列相似。我们相信，从 PROSa 提取的 RPS 患者的 HRQoL 数据可转移到临床实践中。
