National Clinical Research Center for Geriatrics (WCHSCU), Sichuan University West China Hospital, Chengdu, Sichuan, China.
The No.1 Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
BMJ Open. 2022 Jun 14;12(6):e055407. doi: 10.1136/bmjopen-2021-055407.
The West China longevity and ageing procedure (WCLAP) cohort study aims to provide guidance for older adults in western China with the aim of improving quality of life, reducing the burden of family care, summarising the characteristics of longevity lifestyles, building a Chinese-longevity-population biobank and exploring the mechanisms underlying population ageing.
Since the establishment of the WCLAP research baseline in 2018, a population of 1537 adults aged 80 years and above, living in the community, have been enrolled in the programme as research participants. Of these, 231 are aged 100 years and above. Participants are followed up every year.
WCLAP data are collected in five hospital research subcentres strategically located adjacent to the national 'Longevity Townships' of Chengdu Ziyang, Leshan, Yibin and Pengshan. Data collection included a comprehensive assessment of the participant's health (including physical, psychological, social and common chronic disease assessments), instrumental tests (body composition and muscle percentage) and the collection of biomedical-biobank samples (include blood, urine, faeces, hair and urine).
Through the annual cohort follow-up, survival-related information is collected at a group level. Analysis of biological samples facilitates biological characterisation at the microscopic level through proteomics, metabolomics, genomics and other techniques. Baseline data, group-level follow-up data and microbiological examination data are integrated together to provide an evaluation tool, exploring sarcopenia, disability, dementia, caregiver burden, ageing biomarkers and other influencing factors.
2018-463; ChiCTR1900020754.
华西长寿与衰老计划（WCLAP）队列研究旨在为中国西部的老年人提供指导，以提高生活质量，减轻家庭护理负担，总结长寿生活方式的特点，建立中国长寿人群生物库，并探索人口老龄化的机制。
自 2018 年 WCLAP 研究基线建立以来，已有 1537 名 80 岁及以上、居住在社区的成年人作为研究参与者纳入该计划。其中 231 人年龄在 100 岁及以上。参与者每年接受随访。
WCLAP 数据是在五个位于成都资阳、乐山、宜宾和彭山的国家“长寿镇”附近的医院研究分中心收集的。数据收集包括对参与者健康状况的全面评估（包括身体、心理、社会和常见慢性疾病评估）、仪器测试（身体成分和肌肉百分比）以及生物医学生物库样本的收集（包括血液、尿液、粪便、头发和尿液）。
通过每年的队列随访，在群体水平上收集与生存相关的信息。分析生物样本可以通过蛋白质组学、代谢组学、基因组学等技术在微观水平上进行生物特征分析。将基线数据、群体水平随访数据和微生物检查数据整合在一起，提供一个评估工具，探索肌少症、残疾、痴呆、照顾者负担、衰老生物标志物和其他影响因素。
2018-463；ChiCTR1900020754。
