葫芦脲通过靶向 N 端热段抑制胰岛淀粉样多肽聚集并减轻细胞毒性。
Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
机构信息
Department of Chemistry, New York University, New York, NY, 10003, USA.
Present Address: Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India.
出版信息
Chemistry. 2022 Jul 6;28(38):e202201698. doi: 10.1002/chem.202201698. Epub 2022 Jun 14.
Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.
本期的封面特邀嘉宾是纽约大学的 Hamilton 教授团队。该图片描绘了瓜环[7]脲如何抑制胰岛淀粉样多肽的自组装，从而挽救大鼠胰岛素瘤细胞（一种胰腺β细胞模型）免受组装相关的细胞毒性。全文请阅读 10.1002/chem.202200456。
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