Kirk L K, Lewis B A, Ross D A, Morrison M A
Food Chem Toxicol. 1987 Mar;25(3):233-9. doi: 10.1016/0278-6915(87)90088-3.
Caprolactam (2-oxohexamethylenimine) is metabolized in the rat partly to 4-hydroxycaprolactam or the corresponding free acid. The 4-hydroxy metabolite rearranges spontaneously in acidic aqueous medium to an equilibrium mixture of which 6-amino-gamma-caprolactone is the major component and 6-amino-4-hydroxyhexanoic acid is a minor component. Approximately 16% of the caprolactam ingested daily by rats fed a diet containing 3% caprolactam was excreted as the 4-hydroxy metabolite and a small amount was excreted as the non-hydroxylated acid, 6-aminohexanoic acid. The metabolites were isolated by ion-exchange chromatography and identified by gas chromatography-mass spectroscopy and infra-red and nuclear magnetic resonance spectroscopy.
己内酰胺（2-氧代六亚甲基亚胺）在大鼠体内部分代谢为4-羟基己内酰胺或相应的游离酸。4-羟基代谢产物在酸性水介质中自发重排为平衡混合物，其中6-氨基-γ-己内酯是主要成分，6-氨基-4-羟基己酸是次要成分。喂食含3%己内酰胺日粮的大鼠每天摄入的己内酰胺中，约16%以4-羟基代谢产物的形式排泄，少量以非羟基化酸6-氨基己酸的形式排泄。代谢产物通过离子交换色谱法分离，并通过气相色谱-质谱、红外光谱和核磁共振光谱进行鉴定。
