Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences; Shanghai, China; University of Chinese Academy of Sciences; Beijing, China.
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences; Shanghai, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology; Shanghai, China.
Trends Neurosci. 2022 Aug;45(8):594-607. doi: 10.1016/j.tins.2022.05.005. Epub 2022 Jun 12.
The somatosensory system processes diverse types of information including mechanical, thermal, and chemical signals. It has an essential role in sensory perception and body movement and, thus, is crucial for organism survival. The neural network for processing somatosensory information comprises multiple key nodes. Spinal projection neurons represent the key node for transmitting somatosensory information from the periphery to the brain. Although the anatomy of spinal ascending pathways has been characterized, the mechanisms underlying somatosensory information processing by spinal ascending pathways are incompletely understood. Recent studies have begun to reveal the diversity of spinal ascending pathways and their functional roles in somatosensory information processing. Here, we review the anatomic, molecular, and functional characteristics of spinal ascending pathways.
躯体感觉系统处理多种类型的信息，包括机械、热和化学信号。它在感觉感知和身体运动中起着重要作用，因此对生物体的生存至关重要。用于处理躯体感觉信息的神经网络包括多个关键节点。脊髓投射神经元代表将躯体感觉信息从外周传递到大脑的关键节点。尽管已经描述了脊髓上行通路的解剖结构，但对脊髓上行通路处理躯体感觉信息的机制仍不完全了解。最近的研究开始揭示脊髓上行通路的多样性及其在躯体感觉信息处理中的功能作用。在这里，我们回顾了脊髓上行通路的解剖、分子和功能特征。
