Ducloux-Lebon Benjamin, Brazier Franck, Tamarit Clémence, Sabbagh Charles, Fumery Mathurin, Chatelain Denis
Service d'anatomie et cytologie pathologiques, CHU Amiens Nord, Place Victor-Pauchet, 80000 Amiens, France.
Service d'hépato gastroentérologie, CHU Amiens Sud, 1, rond-point du Professeur Christian-Cabrol, 80054 Amiens Cedex 1, France.
Ann Pathol. 2023 Jan;43(1):29-33. doi: 10.1016/j.annpat.2022.05.005. Epub 2022 Jun 11.
Patients with chronic inflammatory diseases (IBD) of the digestive tract are known to have an increased risk of colorectal cancer. These are usually adenocarcinomas, and the occurrence of malignant mesenchymal tumours, particularly leiomyosarcomas, is exceptional. We report one case in a 40-year-old woman, followed for 9 years for ulcerative colitis. The tumour measured 2cm in length and infiltrated the entire rectal wall as far as the subserosa. It was composed of fusiform cells, with 5 mitoses for 10 fields at ×400 magnification, and expressing actin, desmin and caldesmone under immunohistochemical study. We review the 2 cases of leiomyosarcomas associated with Crohn's disease and 3 cases developed during ulcerative colitis published in the literature.
已知患有消化道慢性炎症性疾病（IBD）的患者患结直肠癌的风险会增加。这些通常是腺癌，而恶性间充质肿瘤的发生，尤其是平滑肌肉瘤，极为罕见。我们报告了一例40岁女性病例，该患者因溃疡性结肠炎接受了9年的随访。肿瘤长2厘米，浸润整个直肠壁直至浆膜下层。它由梭形细胞组成，在×400倍放大下每10个视野有5个有丝分裂象，免疫组织化学研究显示其表达肌动蛋白、结蛋白和钙调蛋白。我们回顾了文献中报道的2例与克罗恩病相关的平滑肌肉瘤病例以及3例在溃疡性结肠炎期间发生的病例。
