Department of Ophthalmology, Katip Celebi University Ataturk Teaching and Research Hospital, Karabaglar, Izmir, Turkey.
Department of Ophthalmology, Katip Celebi University Ataturk Teaching and Research Hospital, Karabaglar, Izmir, Turkey.
J Fr Ophtalmol. 2022 Oct;45(8):915-920. doi: 10.1016/j.jfo.2022.03.004. Epub 2022 Jun 11.
To evaluate the Meibomian glands and presence of dry eye in patients with unilateral pseudoexfoliation.
The study included 32 patients with clinical pseudoexfoliation (PEX) in one eye and 30 controls. Schirmer and tear film break-up time (TBUT) tests were performed, along with a detailed ophthalmological examination, meibography and evaluation of areas of meibomian gland loss. Subjective symptoms were evaluated using the ocular surface disease index (OSDI).
Schirmer test results for eyes with or without PEX were similar (10.438±4.47mm and 11.563±4.35mm, respectively), vs. 15.967±9.75mm in the control group. While measurements of TBUT were found to be similar in both eyes of the patient group (6.188±2.66s in eyes with PEX and 6.250±1.87s in eyes without PEX), this was 8.233±2.66s in the control group. Schirmer and TBUT test results were found to be significantly lower in both eyes of patients with unilateral pseudoexfoliation compared to control eyes. The rate of meibomian gland loss in the upper and lower eyelids in the patient group was found to be significantly higher than in the control group. Similarly, meiboscores of both eyelids in the control group were significantly lower than those in patient group; however, there were no differences between patient eyes with or without pseudoexfoliation.
The patients with unilateral pseudoexfoliation had a significant loss of meibomian gland area in both eyes compared to the control group, and their meiboscore was higher. It should be considered that meibomian gland loss may be one of the causes of dry eye in patients with pseudoexfoliation.
评估单侧假性剥脱症患者的睑板腺功能和干眼情况。
本研究纳入了 32 例单眼临床假性剥脱症（PEX）患者和 30 例对照者。对患者进行了 Schirmer 试验和泪膜破裂时间（TBUT）检查，以及详细的眼科检查、睑板腺照相和睑板腺缺失面积评估，并使用眼表疾病指数（OSDI）评估患者的主观症状。
有或无 PEX 的患眼的 Schirmer 试验结果相似（分别为 10.438±4.47mm 和 11.563±4.35mm），而对照组为 15.967±9.75mm。虽然患者组双眼的 TBUT 测量值相似（PEX 眼为 6.188±2.66s，无 PEX 眼为 6.250±1.87s），但对照组为 8.233±2.66s。单侧假性剥脱症患者双眼的 Schirmer 和 TBUT 试验结果明显低于对照组。患者组上下眼睑的睑板腺缺失率明显高于对照组。同样，对照组上下眼睑的睑板腺评分均明显低于患者组，但 PEX 眼与无 PEX 眼之间无差异。
与对照组相比，单侧假性剥脱症患者双眼的睑板腺缺失面积明显更大，且其睑板腺评分更高。应考虑到睑板腺缺失可能是假性剥脱症患者发生干眼的原因之一。
