Valenta L J, Elias A N, Iyer K
Horm Res. 1987;25(2):97-104. doi: 10.1159/000180639.
Adrenal vein catheterization data from 2 patients with adrenocortical adenomas causing Cushing's syndrome are presented and the electron-microscopic features of one of the tumors are described. Based on the catheterization data both tumors produced all three classes of adrenal steroids (mineralocorticoids, glucocorticoids and sex steroids). Electron-microscopic examination of the tumor cells suggested an origin from the zona fasciculata. If one accepts the theory of a common cellular origin of adrenal tumors, then the pattern of steroidogenesis would indicate that the postulated original 'stem' cell retains the potential of secreting all classes of adrenocortical steroids. The clinical presentation of such tumors would thus reflect the hypersecretion of one of the steroid classes relative to the others.
本文呈现了2例由肾上腺皮质腺瘤导致库欣综合征患者的肾上腺静脉插管数据，并描述了其中1例肿瘤的电子显微镜特征。基于插管数据，这两个肿瘤均能产生所有三类肾上腺类固醇（盐皮质激素、糖皮质激素和性激素）。对肿瘤细胞的电子显微镜检查提示其起源于束状带。如果接受肾上腺肿瘤具有共同细胞起源的理论，那么类固醇生成模式将表明假定的原始“干细胞”保留了分泌所有类肾上腺皮质类固醇的潜能。因此，这类肿瘤的临床表现将反映出某一类类固醇相对于其他类固醇的分泌过多。
