Trave Ilaria, Micalizzi Claudia, Molle Mattia, Castelli Riccardo, Cozzani Emanuele, Parodi Aurora
Section of Dermatology, Department of Health Sciences, University of Genoa, IRCCS, Genoa, Italy.
Case Rep Dermatol. 2022 May 9;14(2):112-116. doi: 10.1159/000523799. eCollection 2022 May-Aug.
Acne fulminans (AF) is a rare and severe form of inflammatory acne that typically occurs in male adolescents with acne vulgaris and is characterized by the sudden onset of painful, bleeding, and ulcerated lesions. It has been described very rarely in association with hidradenitis suppurativa (HS). Its onset may be induced by drugs, particularly isotretinoin. We present a case of a 16-year-old patient with HS who developed AF following initiation of antibiotic therapy with lymecycline. In the literature, only 2 patients who developed a coexistence of AF and HS have been reported, and there are only 2 other similar cases of AF induced by doxycycline and lymecycline. We consider our case to be of particular interest not only because of the very rare concomitant presence of AF and HS but also because AF was induced by lymecycline, a drug commonly used to treat both acne and HS, and described only once as a drug responsible for AF, so it is an aspect that deserves to be considered by the clinician dealing with similar conditions.
暴发性痤疮（AF）是一种罕见且严重的炎症性痤疮，通常发生于患有寻常痤疮的男性青少年，其特征为突然出现疼痛、出血及溃疡性病损。与化脓性汗腺炎（HS）相关的情况极为罕见。其发病可能由药物诱发，尤其是异维A酸。我们报告一例16岁患有HS的患者，在开始使用赖甲环素进行抗生素治疗后发生了AF。在文献中，仅报道过2例AF与HS并存的患者，另外还有2例由多西环素和赖甲环素诱发AF的类似病例。我们认为我们的病例特别值得关注，不仅因为AF与HS同时存在的情况极为罕见，还因为AF是由赖甲环素诱发的，赖甲环素是一种常用于治疗痤疮和HS的药物，且仅被描述过一次作为导致AF的药物，所以这是一个值得处理类似情况的临床医生考虑的方面。
