Vaidya Neel S, Daneshmand Arvin, Epstein Randy J, Majmudar Parag A, Belin Michael W, Parsons Edward C, Rubinfeld Roy S
Chicago Cornea Consultants, Highland Park, IL, USA.
Department of Ophthalmology, Rush University Medical Center, Chicago, IL, USA.
Clin Ophthalmol. 2022 Jun 8;16:1829-1835. doi: 10.2147/OPTH.S359710. eCollection 2022.
To assess the change in corneal pachymetry after a novel epithelium-on (EpiSmart) corneal crosslinking procedure (CXL).
Eyes treated as part of the open-label, non-controlled arm of the study "Collagen Crosslinking with Ultraviolet-A in Asymmetric Corneas" (NCT01097447) were examined at baseline, 3-, 6- and 12-months post-CXL. Thinnest pachymetry readings based on Pentacam (OCULUS GmbH, Wetzlar, Germany) were recorded.
A total of 101 eyes met the study inclusion criteria. Thinnest pachymetric readings at baseline averaged 451 ± 50 microns. The mean (± SD) minimum thickness was 450 ± 46 microns at 3 months, 452 ± 47 microns at 6 months, and 451 ± 48 microns at 12 months post-CXL. The changes from baseline (mean ± SE) at 3, 6, and 12 months post-CXL were -1.2 ± 1.5 microns, 0.5 ± 1.6 microns, and 0.4 ± 1.6 microns, respectively. Student's t-tests showed no statistically significant change in pachymetry from baseline for any exam period.
This study demonstrated that, after EpiSmart epithelium-on CXL, there was no substantial corneal thinning observable on Scheimpflug tomography out to 12 months.
评估一种新型表层角膜交联术（EpiSmart）后角膜厚度测量值的变化。
在“非对称角膜的紫外线A胶原交联术”（NCT01097447）研究的开放标签、非对照组中接受治疗的眼睛，在角膜交联术后基线、3个月、6个月和12个月时进行检查。记录基于Pentacam（德国韦茨拉尔的OCULUS GmbH公司）的最薄角膜厚度测量值。
共有101只眼睛符合研究纳入标准。基线时最薄角膜厚度测量值平均为451±50微米。角膜交联术后3个月时平均（±标准差）最小厚度为450±46微米，6个月时为452±47微米，12个月时为451±48微米。角膜交联术后3个月、6个月和12个月时相对于基线的变化（平均值±标准误）分别为-1.2±1.5微米、0.5±1.6微米和0.4±1.6微米。学生t检验显示，在任何检查时间段，角膜厚度测量值与基线相比均无统计学上的显著变化。
本研究表明，在进行EpiSmart表层角膜交联术后，至12个月时，在Scheimpflug断层扫描中未观察到明显的角膜变薄。
