肾脏疾病中的静脉血栓栓塞与遗传易感性
Venous Thromboembolism in Kidney Diseases and Genetic Predisposition.
作者信息
Wu Tingting, Tang Liang V, Hu Yu
机构信息
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Kidney Dis (Basel). 2022 Apr 11;8(3):181-189. doi: 10.1159/000523777. eCollection 2022 May.
BACKGROUND
Many renal diseases have been associated with profound clinical effects on thrombosis. To our knowledge, patients with nephrotic syndrome (NS) and chronic kidney disease (CKD) display an elevated risk of vein thrombosis, which is among the common causes of mortality in patients with renal diseases. In addition, venous thrombosis, as a complication, has also been reported in a variety of other renal diseases such as glomerulonephritis without the NS, hypertensive nephropathy, and polycystic kidney disease. With the increasing incidence of kidney diseases and the deeper understanding of the disease, clinicians are becoming more and more aware of the complications of thrombus formation in kidney disease.
SUMMARY
We reviewed recent publications of vein thrombosis in kidney diseases, including primary and secondary glomerular diseases, CKD, hereditary kidney disease, renal transplantation, and hemodialysis-induced, catheter-related thrombus, focusing mainly on the main clinical manifestations, possible mechanisms, related risk factors as well as hereditary influencing factors.
KEY MESSAGES
Vein thrombosis is a complicated complication of a wide spectrum of kidney diseases due to different possible underlying mechanisms.
背景
许多肾脏疾病都与对血栓形成产生深远的临床影响有关。据我们所知，肾病综合征（NS）和慢性肾脏病（CKD）患者发生静脉血栓的风险升高，这是肾脏疾病患者常见的死亡原因之一。此外，静脉血栓作为一种并发症，在多种其他肾脏疾病中也有报道，如无NS的肾小球肾炎、高血压肾病和多囊肾病。随着肾脏疾病发病率的上升以及对该疾病认识的深入，临床医生越来越意识到肾脏疾病中血栓形成的并发症。
总结
我们回顾了近期关于肾脏疾病中静脉血栓形成的出版物，包括原发性和继发性肾小球疾病、CKD、遗传性肾脏疾病、肾移植以及血液透析引起的、与导管相关的血栓，主要关注其主要临床表现、可能机制、相关危险因素以及遗传影响因素。
关键信息
由于不同的潜在机制，静脉血栓是多种肾脏疾病的复杂并发症。
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