Centre for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana-124001, India.
Recent Pat Anticancer Drug Discov. 2023;18(3):325-342. doi: 10.2174/157489281703220610170559.
Chemotherapeutic drugs are principally intended to treat breast cancer. However, sooner or later, tumor drug resistance developed. These chemo drugs are effective but with numerous side effects. Breast cancer care may be extremely difficult since recurring cancer is frequently pre-treated with powerful agents. Cancer cells acquire high resistance to earlier therapies, necessitating alternative and more powerful drugs. Nanoparticles (NPs) as a medication delivery technology can overcome medication resistance in breast cancer and significantly reduce the effective dose. The off-targeted nature of chemo drugs can be resolved by encapsulating or attaching chemo drugs in nanocarriers, specifically targeting breast cancer cells.
This review highlights various chemo drugs for breast cancer and their encapsulation or bioconjugation with nanoparticles for its targeted delivery.
Nanoparticles may subsist valuable abet in breast cancer management in this regard. Given that traditional chemotherapy approaches have been demonstrated to have several side effects and defects during treatment, the NPs-mediated drug delivery mechanism is a possible contender for replacement as a new technique.
化疗药物主要用于治疗乳腺癌。然而，肿瘤迟早会产生耐药性。这些化疗药物虽然有效，但副作用也很多。由于复发性癌症经常使用强力药物进行预处理，因此乳腺癌的治疗可能非常困难。癌细胞对早期治疗产生了很高的耐药性，需要使用替代的、更有效的药物。纳米颗粒（NPs）作为一种药物递送技术，可以克服乳腺癌中的药物耐药性，并显著降低有效剂量。通过将化疗药物包封或附着在纳米载体中，可以解决化疗药物的非靶向性问题，从而特异性地靶向乳腺癌细胞。
本文综述了各种用于乳腺癌的化疗药物及其与纳米颗粒的包封或生物偶联，以实现其靶向递送。
在这方面，纳米颗粒可能在乳腺癌的管理中具有重要的辅助作用。鉴于传统的化疗方法在治疗过程中已被证明存在多种副作用和缺陷，因此 NPs 介导的药物递送机制可能成为一种有前途的替代技术。
