State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University / International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China / Guangdong Key Lab of Traditional Chinese Medicine Information Technology / International Science and Technology Cooperation Base of Guangdong Province / School of Pharmacy, Jinan University, Guangdong, Guangzhou 510632, China.
Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China.
Biomed Pharmacother. 2024 Oct;179:117327. doi: 10.1016/j.biopha.2024.117327. Epub 2024 Aug 30.
Breast cancer (BC) is one of the most frequently diagnosed cancers in women. Chemotherapy continues to be the treatment of choice for clinically combating it. Nevertheless, the chemotherapy process is frequently hindered by multidrug resistance, thereby impacting the effectiveness of the treatment. Multidrug resistance (MDR) refers to the phenomenon in which malignant tumour cells develop resistance to anticancer drugs after one single exposure. It can occur with a broad range of chemotherapeutic drugs with distinct chemical structures and mechanisms of action, and it is one of the major causes of treatment failure and disease relapse. Research has long been focused on overcoming MDR by using multiple drug combinations, but this approach is often associated with serious side effects. Therefore, there is a pressing need for in-depth research into the mechanisms of MDR, as well as the development of new drugs to reverse MDR and improve the efficacy of breast cancer chemotherapy. This article reviews the mechanisms of multidrug resistance and explores the application of nano-drug delivery system (NDDS) to overcome MDR in breast cancer. The aim is to offer a valuable reference for further research endeavours.
乳腺癌（BC）是女性最常被诊断出的癌症之一。化疗仍然是临床对抗乳腺癌的首选治疗方法。然而，化疗过程常常受到多药耐药的阻碍，从而影响治疗的效果。多药耐药（MDR）是指恶性肿瘤细胞在单次接触抗癌药物后对其产生耐药性的现象。它可以发生在具有不同化学结构和作用机制的广泛的化疗药物中，是治疗失败和疾病复发的主要原因之一。长期以来，人们一直致力于通过使用多种药物组合来克服 MDR，但这种方法常常伴随着严重的副作用。因此，深入研究 MDR 的机制以及开发新的药物来逆转 MDR 并提高乳腺癌化疗的疗效迫在眉睫。本文综述了多药耐药的机制，并探讨了纳米药物递送系统（NDDS）在克服乳腺癌多药耐药中的应用。目的是为进一步的研究工作提供有价值的参考。
