Litchinko Alexis, Peloso Andrea, Toso Christian, Compagnon Philippe
Service de chirurgie viscérale, Hôpitaux universitaires de Genève, 1211 Genève 14.
Service de transplantation, Hôpitaux universitaires de Genève, 1211 Genève 14.
Rev Med Suisse. 2022 Jun 15;18(786):1210-1217. doi: 10.53738/REVMED.2022.18.786.1210.
This article provides an overview of recent advances in the diagnosis and treatment of extrahepatic cholangiocarcinomas (EH-CCAs), focusing on the role of endoscopy, surgery, and transplantation. It reviews optimal evaluation and management of patients with EH-CCA, including a careful integration of clinical information, imaging studies, cytology and/or histology, as well as a coordinated multidisciplinary approach. It reviews additional therapy such as radio- or chemotherapy either in the neoadjuvant or adjuvant setting. Furthermore, it addresses palliative approaches as well as emerging targeted therapy and immunotherapy. EH-CCAs account for nearly 90% of biliary tract malignancies and present an ongoing challenge for hepatobiliary surgeons.
本文概述了肝外胆管癌（EH-CCA）诊断和治疗的最新进展，重点关注内镜检查、手术和移植的作用。它回顾了EH-CCA患者的最佳评估和管理，包括仔细整合临床信息、影像学研究、细胞学和/或组织学，以及协调的多学科方法。它回顾了新辅助或辅助治疗环境下的放射治疗或化疗等额外治疗。此外，它还讨论了姑息治疗方法以及新兴的靶向治疗和免疫治疗。EH-CCA占胆道恶性肿瘤的近90%，对肝胆外科医生来说仍然是一个持续的挑战。
