Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore.
Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme.
J Hypertens. 2022 Jun 1;40(6):1212-1222. doi: 10.1097/HJH.0000000000003134.
To evaluate the relationship of the levels of maternal alcohol consumption during the 1 year before pregnancy recognition with childhood cardiorenal, metabolic, and neurocognitive health.
In 1106 women and their children from the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort, quantity of maternal alcohol consumption in the 12 months prior to pregnancy recognition was categorized as high (≥75th percentile: 1.9 g/day), low (<1.9 g/day), and none, and frequency of alcohol consumption was categorized as high (≥2-3 times/week), low (<2-3 times/week), and none. Offspring MRI-based abdominal fat depot, kidney, and brain volumes, blood pressure, metabolic syndrome score, and cognitive intelligence scores were assessed. Child prehypertension/hypertension at age 6 years was defined using a simplified pediatric threshold of 110/70 mmHg.
The average maternal alcohol consumption in the year prior to pregnancy recognition was 2.5 g/day, which is lower than the daily maximal limit of one standard drink (10 g) recommended for women by Singapore's Ministry of Health. After adjusting for participant characteristics, alcohol consumption at least 1.9 g/day was associated with over two-fold higher risk (risk ratio = 2.18, P = 0.013) of child prehypertension and 15% greater kidney growth between early infancy and age 6 years (P = 0.040) compared with abstinence. Alcohol consumption was not associated with metabolic and neurocognitive health at age 6-7 years. The associations with high frequency of alcohol consumption were concordant with those obtained for quantity of alcohol consumption.
Maternal self-reported alcohol consumption at least 1.9 g/day prior to pregnancy recognition was associated with increased risk of child prehypertension and rapid kidney growth. Our findings highlight the potential detrimental effects of low periconceptional alcohol consumption, below national guidelines on offspring cardiorenal health.
评估妊娠前 1 年母亲饮酒量与儿童心肾、代谢和神经认知健康的关系。
在新加坡走向健康结局母婴队列研究的 1106 名女性及其子女中，将妊娠前 12 个月内母亲的酒精摄入量分为高（≥第 75 百分位数：1.9g/天）、低（<1.9g/天）和无，饮酒频率分为高（≥每周 2-3 次）、低（<每周 2-3 次）和无。评估后代 MRI 测量的腹部脂肪、肾脏和大脑体积、血压、代谢综合征评分和认知智力评分。6 岁时儿童高血压前期/高血压定义为采用简化的儿科标准，即收缩压/舒张压>110/70mmHg。
妊娠前一年母亲平均酒精摄入量为 2.5g/天，低于新加坡卫生部推荐的女性每日最大限量 1 标准饮料（10g）。在调整参与者特征后，每天至少饮酒 1.9g 与儿童高血压前期风险增加两倍以上（风险比=2.18，P=0.013）和婴儿期至 6 岁时肾脏生长增加 15%（P=0.040）相关，与戒酒相比。酒精摄入与 6-7 岁时的代谢和神经认知健康无关。高频率饮酒与酒精摄入量的相关性一致。
妊娠前至少 1.9g/天的母亲自我报告饮酒量与儿童高血压前期和肾脏快速生长的风险增加有关。我们的研究结果强调了低围孕期酒精摄入（低于国家对后代心肾健康的指导方针）对后代健康的潜在有害影响。
