Proud D, Kagey-Sobotka A, Naclerio R M, Lichtenstein L M
Int Arch Allergy Appl Immunol. 1987;82(3-4):493-7. doi: 10.1159/000234264.
We have used a model of nasal provocation to study the effects of pharmacologic interventions upon various types of inflammatory reactions of the upper airways. Pretreatment of allergic individuals with aspirin reduces the levels of prostaglandins in nasal secretions during the immediate allergic response but has no effect on symptoms. Theophylline and azatadine both reduce symptoms and the levels of mast cell mediators during the allergic response. By contrast, azatadine has no effect on symptoms or mediator levels during the response to challenge with cold, dry air, suggesting different mechanisms of mast cell activation in response to allergen and cold, dry air. Both topical and systemic steroids are effective in reducing symptoms and mediators during the late allergic response, but topical steroids also significantly inhibit the immediate response. Nasal challenge provides a convenient, relatively noninvasive method to study inflammatory reactions of the upper airways.
我们使用了鼻激发模型来研究药物干预对上呼吸道各种炎症反应的影响。用阿司匹林对过敏个体进行预处理可降低速发型过敏反应期间鼻分泌物中前列腺素的水平，但对症状无影响。在过敏反应期间，茶碱和氮卓斯汀均可减轻症状并降低肥大细胞介质的水平。相比之下，氮卓斯汀在对冷干空气激发的反应期间对症状或介质水平没有影响，这表明肥大细胞对过敏原和冷干空气的激活机制不同。局部和全身用类固醇在减轻迟发型过敏反应期间的症状和介质方面均有效，但局部用类固醇也能显著抑制速发型反应。鼻激发提供了一种方便、相对无创的方法来研究上呼吸道的炎症反应。
