抗黑色素瘤分化相关基因 5 抗体阳性间质性肺病与 COVID-19 mRNA 疫苗接种后。
Antimelanoma Differentiation-Associated Gene 5 Antibody-Positive Interstitial Lung Disease After Vaccination With COVID-19 mRNA Vaccines.
机构信息
T. Kitajima, MD, A. Funauchi, MD, S. Marumo, MD, PhD, M. Fukui, MD, PhD, Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute;
T. Kitajima, MD, A. Funauchi, MD, S. Marumo, MD, PhD, M. Fukui, MD, PhD, Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute.
出版信息
J Rheumatol. 2022 Oct;49(10):1158-1162. doi: 10.3899/jrheum.220259. Epub 2022 Jun 15.
OBJECTIVE
Melanoma differentiation-associated gene 5 (MDA5) is a viral RNA sensor induced by SARS-CoV-2. Similarities have been reported between the clinical presentations of coronavirus disease 2019 (COVID-19) pneumonia and anti-MDA5 antibody-positive interstitial lung disease (anti-MDA5-ILD). However, it is unknown whether COVID-19 mRNA vaccines are associated with anti-MDA5-ILD.
METHODS
We retrospectively reviewed consecutive patients with anti-MDA5-ILD admitted to our hospital between April 2017 and March 2022. In addition, we investigated the clinical presentations of patients who developed anti-MDA5-ILD after vaccination with COVID-19 mRNA vaccines. We also examined the annual number of anti-MDA5-ILD cases before and after the COVID-19 vaccination campaign.
RESULTS
Nine patients with anti-MDA5-ILD were seen during the study period, of whom 4 developed anti-MDA5-ILD between August and October 2021, approximately 6 to 12 weeks after vaccination with a COVID-19 mRNA vaccine and a few months after the rapid mRNA COVID-19 vaccination campaign in Japan. None of the 4 patients had evidence of SARS-CoV-2 infection. The difference in the annual number of anti-MDA5-ILD cases before vs after the COVID-19 vaccination campaign (1.25 ± 0.96 cases/yr vs 4.0 cases/yr) was not statistically significant ( = 0.08).
CONCLUSION
We encountered 4 cases of anti-MDA5-ILD after COVID-19 vaccination. Further large population studies are needed to clarify the relationship between anti-MDA5-ILD and vaccination with COVID-19 mRNA vaccines.
目的
黑色素瘤分化相关基因 5（MDA5）是一种由 SARS-CoV-2 诱导的病毒 RNA 传感器。据报道，2019 年冠状病毒病（COVID-19）肺炎和抗 MDA5 抗体阳性间质性肺病（anti-MDA5-ILD）的临床表现之间存在相似之处。然而，尚不清楚 COVID-19 mRNA 疫苗是否与抗 MDA5-ILD 相关。
方法
我们回顾性分析了 2017 年 4 月至 2022 年 3 月期间我院收治的连续抗 MDA5-ILD 患者。此外，我们还调查了接种 COVID-19 mRNA 疫苗后发生抗 MDA5-ILD 的患者的临床表现。我们还检查了 COVID-19 疫苗接种运动前后抗 MDA5-ILD 病例的年发病数。
结果
在研究期间，共观察到 9 例抗 MDA5-ILD 患者，其中 4 例患者于 2021 年 8 月至 10 月接种 COVID-19 mRNA 疫苗后约 6 至 12 周、日本快速 mRNA COVID-19 疫苗接种运动后数月内发生抗 MDA5-ILD。这 4 名患者均无 SARS-CoV-2 感染证据。COVID-19 疫苗接种前后抗 MDA5-ILD 年发病数（1.25 ± 0.96 例/年 vs 4.0 例/年）的差异无统计学意义（ = 0.08）。
结论
我们在 COVID-19 疫苗接种后遇到了 4 例抗 MDA5-ILD 病例。需要进一步进行大规模人群研究，以阐明抗 MDA5-ILD 与 COVID-19 mRNA 疫苗接种之间的关系。
Zotero 插件