Cui Zhenzhen, Liu Le, Chen Xi, Zeng Haiyan, Zheng Shizhu, Wu De
Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Pediatric, Anhui Province Maternity and Child Health Hospital, Hefei, China.
Front Hum Neurosci. 2022 May 30;16:900214. doi: 10.3389/fnhum.2022.900214. eCollection 2022.
To explore the effect of modified constraint-induced movement therapy (mCIMT) on upper limbs residual dysfunction for infancy with the sequelas of unilateral brachial plexus injury (uBPI).
Single blind randomized controlled trial of mCIMT vs. standard care. An enrolling 31 infants with a uBPI exhibiting residual dysfunction of the affected upper limb for over 6 months was conducted. And functional outcomes pertaining to the affected upper limb were assessed AMS, GRES, RHS, and MSS at 0, 3, and 6 months after treatment.
No differences were found in baseline (acquisition phase) AMS, MSS, GRES, or RHS between the control and mCIMT groups [(1, 14) = 0.062, = 0.086; (1, 14) = 0.483, = 0.499; (1, 14) = 0.272, = 0.610; = -0.336, = 7.373]. At the 3- and 6-month follow-up time points, AMS, MSS, and GRES scores were significantly improved over baseline in both groups [mCIMT: (2, 30) = 183.750, 128.614, 110.085, < 0.05; Control: (2, 28) = 204.007, 75.246, 51.070, < 0.05]. No significant differences were found between two treatment groups at the 3-month follow-up time point [(1, 14) = 0.565, = 0.465; (1, 14) = 0.228, = 0.641; (1, 14) = 0.713, = 0.413; = -0.666, = 0.505]. However, at the 6-month follow-up time point, AMS and MSS scores were significantly improved in the mCIMT group relative to the control group [(1, 14) = 8.077, = 0.013; (1, 14) = 18.692, = 0.001].
mCIMT may benefit the rehabilitation of residual upper limb dysfunction associated with a uBPI in infants.
[www.chictr.org.cn], identifier [ChiCTR1900022119].
探讨改良强制性运动疗法（mCIMT）对单侧臂丛神经损伤（uBPI）后遗症所致婴儿上肢残余功能障碍的影响。
mCIMT与标准护理的单盲随机对照试验。纳入31例uBPI且患侧上肢存在超过6个月残余功能障碍的婴儿。在治疗后0、3和6个月评估患侧上肢的功能结局，包括主动运动量表（AMS）、抓握与释放技能（GRES）、伸手技能（RHS）和手动技能（MSS）。
对照组和mCIMT组在基线（获取阶段）的AMS、MSS、GRES或RHS方面无差异[（1, 14） = 0.062，P = 0.086；（1, 14） = 0.483，P = 0.499；（1, 14） = 0.272，P = 0.610；t = -0.336，P = 7.373]。在3个月和6个月的随访时间点，两组的AMS、MSS和GRES评分均较基线有显著改善[mCIMT组：（2, 30） = 183.750，128.614，110.085，P < 0.05；对照组：（2, 28） = 204.007，75.246，51.070，P < 0.05]。在3个月随访时间点，两个治疗组之间未发现显著差异[（1, 14） = 0.565，P = 0.465；（1, 14） = 0.228，P = 0.641；（1, 14） = 0.713，P = 0.413；t = -0.666，P = 0.505]。然而，在6个月随访时间点，mCIMT组的AMS和MSS评分相对于对照组有显著改善[（1, 14） = 8.077，P = 0.013；（1, 14） = 18.692，P = 0.001]。
mCIMT可能有益于婴儿uBPI相关上肢残余功能障碍的康复。
