新型头部激活剂类似物的合成及其在改进放射免疫分析中的应用。

Synthesis of new head-activator analogues and their application for improved radioimmunoassays.

作者信息

Bodenmüller H, Escher E, Zachmann B, Schilling E

出版信息

Int J Pept Protein Res. 1987 Jan;29(1):140-4. doi: 10.1111/j.1399-3011.1987.tb02240.x.

DOI:10.1111/j.1399-3011.1987.tb02240.x

Abstract

New analogues of head activator were produced for receptor and radioimmunoassay studies. The precursor molecules [(4'-I)Phe11] head activator and [Tyr11] head activator were synthesised for catalytic tritiation and iodination, respectively. With the tracer [(3,5-125 I2)Tyr11] head activator the sensitivity range of the radioimmunoassay was 5-100 fmol.

摘要

为进行受体和放射免疫分析研究，制备了头部激活剂的新类似物。分别合成了前体分子[(4'-I)苯丙氨酸11]头部激活剂和[酪氨酸11]头部激活剂，用于催化氚化和碘化。使用示踪剂[(3,5-125I2)酪氨酸11]头部激活剂，放射免疫分析的灵敏度范围为5-100飞摩尔。