College of Animal Science and Technology, National Experimental Teaching Demonstration Center for Animal Science, Nanjing Agricultural University, Nanjing, China.
Anim Sci J. 2022 Jan-Dec;93(1):e13741. doi: 10.1111/asj.13741.
Dietary curcumin possessing multiple biological activities may be an effective way to alleviate oxidative damage and fat deposition in intrauterine growth retardation (IUGR) finishing pigs. Therefore, this study was conducted to evaluate effects of dietary curcumin on meat quality, antioxidant capacity, and fat deposition of longissimus dorsi muscle in IUGR finishing pigs. Twelve normal birth weight (NBW) and 24 IUGR female piglets at 26 days of age were divided into 3 dietary groups: NBW (basal diet), IUGR (basal diet), and IUGR + Cur (basal diet supplemented with 200 mg/kg curcumin). The trial lasted for 169 days. Results showed that IUGR increased concentrations of malondialdehyde (MDA) and protein carbonyls (PC) and fat deposition in longissimus dorsi muscle. However, curcumin decreased the intramuscular fat content and the levels of MDA and PC and improved meat quality in IUGR pigs. Furthermore, curcumin inhibited the decrease of nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression and decreased peroxisome pro liferator-activated receptors γ (PPARγ) expression in IUGR pigs. These findings suggested that dietary addition of 200 mg/kg curcumin could improve meat quality, alleviate oxidative stress through activating Nrf2 signaling pathway, and reduce fat deposition via inhibiting PPARγ expression in longissimus dorsi muscle of IUGR finishing pigs.
膳食姜黄素具有多种生物学活性，可能是缓解宫内生长迟缓（IUGR）育肥猪氧化损伤和脂肪沉积的有效方法。因此，本研究旨在评估膳食姜黄素对 IUGR 育肥猪背最长肌肉品质、抗氧化能力和脂肪沉积的影响。将 12 头正常出生体重（NBW）和 24 头 IUGR 雌性仔猪在 26 日龄时分为 3 组饲粮：NBW（基础饲粮）、IUGR（基础饲粮）和 IUGR+Cur（基础饲粮添加 200mg/kg 姜黄素）。试验持续 169 天。结果表明，IUGR 增加了背最长肌中丙二醛（MDA）和蛋白质羰基（PC）的浓度和脂肪沉积。然而，姜黄素降低了 IUGR 猪的肌内脂肪含量以及 MDA 和 PC 的水平，并改善了肉品质。此外，姜黄素抑制了 IUGR 猪核因子红细胞 2 相关因子 2（Nrf2）蛋白表达的降低，并降低了过氧化物酶体增殖物激活受体γ（PPARγ）的表达。这些发现表明，饲粮中添加 200mg/kg 姜黄素可以通过激活 Nrf2 信号通路改善肉品质，缓解氧化应激，通过抑制 PPARγ 表达减少背最长肌脂肪沉积。
