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微泡作为一种癌症根除治疗诊断剂的潜力。

The Potential of Microbubbles as a Cancer Eradication Theranostic Agent.

作者信息

Chaudhary Atul, Setia Aseem, Singh Dilpreet, Bhattacharya Sankha

机构信息

Department of Pharmaceutics ISF College of Pharmacy, GT Road (NH-95), GhalKalan,Moga, Punjab 142001, India.

Department of Pharmacy, Shri Rawatpura Sarkar University, Raipur (C.G.) Pincode 492015, India.

出版信息

Pharm Nanotechnol. 2022;10(3):194-209. doi: 10.2174/2211738510666220615154841.

Abstract

Microbubbles are a new kind of delivery system that may be used to treat a variety of illnesses, including cancer. Microbubble is a non-invasive technology that uses microscopic gasfilled colloidal particle bubbles with a size range of less than 100 micrometres. This unique carrier has been used in a variety of applications in the last decade, ranging from basic targeting to ultrasound- mediated drug delivery. The oxygen in the microbubble lasts longer in the water. The drug release mechanism is highly regulated, since it releases the medication only in the appropriate areas, increasing the local impact while reducing drug toxicity. This carrier is exceptional in cancer medication delivery because of its sustained stability, encapsulation efficiency, and drug targeting. In this paper, we provide a comprehensive analysis of microbubble technology, including its manufacturing techniques and use in cancer medication delivery.

摘要

微泡是一种新型的递送系统,可用于治疗包括癌症在内的多种疾病。微泡是一种非侵入性技术,它使用尺寸范围小于100微米的微观充气胶体颗粒气泡。在过去十年中,这种独特的载体已被用于各种应用,从基本靶向到超声介导的药物递送。微泡中的氧气在水中持续时间更长。药物释放机制受到高度调控,因为它仅在适当的区域释放药物,增加局部影响同时降低药物毒性。这种载体在癌症药物递送方面表现出色,因为它具有持续稳定性、包封效率和药物靶向性。在本文中,我们对微泡技术进行了全面分析,包括其制造技术以及在癌症药物递送中的应用。

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