Bencina Goran, Costantino Claudio, Mameli Chiara, Sabale Ugne, Murtagh Janice, Newman Rebecca, Ahern Aideen, Bhaila Rikal, Sanchez Alejandro Orrico, Martinon-Torres Federico, Carias Cristina
Center for Observational and Real-World Evidence (CORE), MSD, Madrid, Spain.
Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Excellence Specialties "G. D'Alessandro," University of Palermo, Palermo, Italy.
Expert Rev Vaccines. 2022 Aug;21(8):1121-1136. doi: 10.1080/14760584.2022.2075851. Epub 2022 Jun 16.
Rotavirus is one of the most common pathogens causing diarrhea in children <5 years and has a major impact on childhood morbidity and mortality. Since the implementation of rotavirus vaccines into childhood immunization programs across Europe, there has been a reduction in rotavirus burden, including hospitalizations, outpatient cases, costs, and deaths.
A systematic literature review identified publications describing the clinical and economic impact of rotavirus vaccinations across Europe, from their introduction in 2006 to the end of 2020. A total of 3,137 articles were identified, of which 46 were included in the review. Included articles reported the impact of rotavirus vaccination on disease in any age group.
Rotavirus vaccination has resulted in substantial reductions in hospitalizations and rotavirus-associated costs across Europe, particularly in children <5 years. There is some evidence of herd protection afforded to older age groups where vaccine uptake is high among infants, highlighting the potential for vaccination to confer a greater societal benefit as programs become more established. Increasing vaccination coverage and continuing investment in widespread rotavirus vaccination programs across countries will likely increase the substantial public health benefits associated with vaccination and further reduce the clinical and economic burden of disease.
轮状病毒是导致5岁以下儿童腹泻的最常见病原体之一，对儿童发病率和死亡率有重大影响。自欧洲将轮状病毒疫苗纳入儿童免疫规划以来，轮状病毒负担有所减轻，包括住院率、门诊病例数、成本和死亡人数。
一项系统性文献综述确定了描述2006年引入至2020年底欧洲轮状病毒疫苗接种的临床和经济影响的出版物。共识别出3137篇文章，其中46篇纳入综述。纳入的文章报告了轮状病毒疫苗接种对任何年龄组疾病的影响。
轮状病毒疫苗接种已使欧洲的住院率和轮状病毒相关成本大幅降低，尤其是在5岁以下儿童中。有证据表明，在婴儿疫苗接种率较高的情况下，老年人群体可获得群体保护，这凸显了随着疫苗接种计划的成熟，疫苗接种有可能带来更大的社会效益。提高疫苗接种覆盖率并持续投资于各国广泛的轮状病毒疫苗接种计划，可能会增加与疫苗接种相关的重大公共卫生效益，并进一步减轻疾病的临床和经济负担。
