Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University) of State Ethnic Affairs Commission, College of Pharmacy, Yanbian University, Yanji, 133002, Jilin, China.
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, Jilin, China.
Inflammopharmacology. 2022 Aug;30(4):1335-1349. doi: 10.1007/s10787-022-01014-x. Epub 2022 Jun 16.
Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues. We examined the effects of Taxifolin, a natural flavonoid mainly existing in vegetables and fruits, on MSU-induced gout. Pretreatment with Taxifolin significantly reduced IL-1β, Caspase-1 and HMGB1 levels, upregulation of autophagy-related protein, LC3, as well as improved phagocytosis of macrophages. This study indicated that Taxifolin-attenuated inflammatory response in MSU-induced acute gout model by decreasing pro-inflammatory cytokine production and promoting the autophagy and phagocytic capacity of macrophages. Dietary supplementation with Taxifolin induces the autophagy and attenuated inflammatory response, which in consequence modulates acute gout. A preventive strategy combining dietary interventions with Taxifolin may offer a potential therapeutic alternative to pharmacological treatment to reduce inflammatory response to gout.
痛风是一种由单钠尿酸盐（MSU）晶体在关节和周围组织沉积引起的慢性疾病。我们研究了 Taxifolin（一种主要存在于蔬菜和水果中的天然类黄酮）对 MSU 诱导的痛风的影响。Taxifolin 预处理显著降低了 IL-1β、Caspase-1 和 HMGB1 水平，上调了自噬相关蛋白 LC3，并增强了巨噬细胞的吞噬作用。本研究表明，Taxifolin 通过减少促炎细胞因子的产生和促进巨噬细胞的自噬和吞噬能力，减轻 MSU 诱导的急性痛风模型中的炎症反应。膳食补充 Taxifolin 可诱导自噬并减轻炎症反应，从而调节急性痛风。将饮食干预与 Taxifolin 相结合的预防策略可能为减少痛风的炎症反应提供一种潜在的治疗替代药物治疗。
