Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, China.
Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, China.
Phytochemistry. 2019 Oct;166:112066. doi: 10.1016/j.phytochem.2019.112066. Epub 2019 Jul 17.
Taxifolin (3,5,7,3,4-pentahydroxy flavanone or dihydroquercetin) is a flavonoid commonly found in onion, milk thistle, French maritime pine bark and Douglas fir bark. It is also used in various commercial preparations like Legalon™, Pycnogenol, and Venoruton. This review focuses on taxifolin's biological activities and related molecular mechanisms. Published literatures were gathered from the scientific databases like PubMed, SciFinder, ScienceDirect, Wiley Online Library, Google Scholar, and Web of Science up to January 2019. Taxifolin showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The anti-cancer activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.
花旗松素（3,5,7,3,4-五羟基黄烷酮或二氢槲皮素）是一种常见的黄酮类化合物，存在于洋葱、奶蓟、法国沿海松树皮和道格拉斯冷杉皮中。它也用于各种商业制剂，如 LegalonTM、Pycnogenol 和 Venoruton。本综述重点介绍花旗松素的生物学活性及相关分子机制。截至 2019 年 1 月，从 PubMed、SciFinder、ScienceDirect、Wiley Online Library、Google Scholar 和 Web of Science 等科学数据库中收集了已发表的文献。花旗松素在炎症、肿瘤、微生物感染、氧化应激、心血管和肝脏疾病的治疗中显示出有前景的药理活性。与使用不同的体外和体内模型评估的其他活性相比，其抗癌活性更为突出。建议使用设计良好的随机临床试验进行药代动力学、深入的分子机制和安全性特征的进一步研究，以开发用于人类使用的药物。
