血清白蛋白与 2 型糖尿病患者糖尿病视网膜病变的相关性：NHANES 2011-2020。
The correlation between serum albumin and diabetic retinopathy among people with type 2 diabetes mellitus: NHANES 2011-2020.
机构信息
Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen, Guangdong, China.
Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China.
出版信息
PLoS One. 2022 Jun 16;17(6):e0270019. doi: 10.1371/journal.pone.0270019. eCollection 2022.
OBJECTIVES
The objective of this research aimed to investigate the correlation involving serum albumin with diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).
METHODS
From 2011 to 2020, the National Health and Nutrition Examination Survey (NHANES) surveyed 45462 participants. We used the relevant data to conduct descriptive statistics, linear regression, and Logistic regression analysis.
RESULTS
After adjusting for age, sex, and race, as well as all other variables, serum albumin was significantly negatively related to DR (P<0.001). Furthermore, after controlling for confounding factors, the third quartile (Q3) and the fourth quartile (Q4) had quite a negative significant relationship with the incidence of DR (P<0.01). The second quartile had a significant positive correlation with DR, whereas the observed negative correlations were not statistically meaningful (P>0.05).
CONCLUSION
Albumin levels in the serum have a quantitatively significant negative correlation with DR. Serum albumin levels in the blood can be used as a reference point for protracted follow-up of people with T2DM.
目的
本研究旨在探讨 2 型糖尿病（T2DM）患者血清白蛋白与糖尿病视网膜病变（DR）的相关性。
方法
2011 年至 2020 年，全国健康和营养调查（NHANES）调查了 45462 名参与者。我们使用相关数据进行描述性统计、线性回归和 Logistic 回归分析。
结果
在调整年龄、性别、种族以及所有其他变量后，血清白蛋白与 DR 呈显著负相关（P<0.001）。此外，在控制混杂因素后，第三四分位数（Q3）和第四四分位数（Q4）与 DR 的发生率呈负显著相关（P<0.01）。第二四分位数与 DR 呈显著正相关，而观察到的负相关无统计学意义（P>0.05）。
结论
血清白蛋白水平与 DR 呈显著负相关。血液中的血清白蛋白水平可作为 T2DM 患者长期随访的参考点。
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