College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China.
Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, Xiamen 361005, China.
ACS Appl Mater Interfaces. 2022 Jun 29;14(25):28581-28590. doi: 10.1021/acsami.2c05814. Epub 2022 Jun 16.
Phototherapy for non-invasive cancer treatment has been extensively studied. An urgent challenge in phototherapy application is to fabricate appropriate targeted agents to achieve efficient therapeutic effect. Herein, a molecular and supramolecular approach for targeting phototherapy was reasonably designed and realized through the axial sulfonate modification of silicon(IV) phthalocyanines (Pcs), followed by supramolecular interaction with albumin. This approach can not only improve the photoactivities (, fluorescence emission and reactive oxygen species production) of the Pcs but also enhance their tumor targeting. Most importantly, one of the deigned Pcs () can target HepG2 cells through dual cell pathways, leading to an extremely high phototoxicity with an EC (, concentration of Pcs to kill 50% of cells under light irradiation) value of 2.0 nM. This finding presents a feasible strategy to realize efficient targeting phototherapy.
光疗在非侵入性癌症治疗方面已得到广泛研究。在光疗应用中，一个紧迫的挑战是制造合适的靶向试剂以实现有效的治疗效果。本文通过硅（IV）酞菁（Pcs）的轴向磺酸盐修饰，随后与白蛋白进行超分子相互作用，合理设计并实现了一种针对光疗的分子和超分子方法。这种方法不仅可以提高 Pcs 的光活性（荧光发射和活性氧的产生），还可以增强它们的肿瘤靶向性。最重要的是，设计的一种 Pcs（）可以通过双重细胞途径靶向 HepG2 细胞，导致极高的光毒性，其 EC（在光照下杀死 50%细胞的 Pcs 浓度）值为 2.0 nM。这一发现为实现高效靶向光疗提供了一种可行的策略。
