Ose E E
J Antibiot (Tokyo). 1987 Feb;40(2):190-4. doi: 10.7164/antibiotics.40.190.
A new macrolide antibiotic, EL-870, 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin, has been prepared by chemical modification of desmycosin. In vitro, against selected animal bacterial pathogens, it inhibited growth of Pasteurella multocida, Pasteurella haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteria at levels of 6.25 micrograms/ml or less. In general, the MICs for Gram-negative enteric bacteria have been greater than 50 micrograms/ml. Concentrations equivalent to 4 X the MIC value were bactericidal for Pasteurella sp. EL-870 had other antibacterial properties which were characteristic of macrolide antibiotics.
一种新的大环内酯类抗生素EL - 870，即20 - 脱氧 - 20 -（3,5 - 二甲基哌啶 - 1 - 基）去甲麦迪霉素，已通过对去甲麦迪霉素进行化学修饰制备而成。在体外，针对选定的动物细菌病原体，它在6.25微克/毫升或更低的浓度下可抑制多杀巴斯德菌、溶血巴斯德菌、猪肺炎支原体、胸膜肺炎放线杆菌、猪链球菌、化脓放线菌及某些其他细菌的生长。一般而言，革兰氏阴性肠道细菌的最低抑菌浓度大于50微克/毫升。相当于最低抑菌浓度值4倍的浓度对巴斯德菌属具有杀菌作用。EL - 870具有大环内酯类抗生素特有的其他抗菌特性。
