克隆崛起：骨髓增生异常综合征继发急性髓系白血病。
Rise of the Clones: Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia.
机构信息
Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.
Division of Hematology, Brigham and Women's Hospital, Boston, Massachusetts.
出版信息
Blood Cancer Discov. 2022 Jul 6;3(4):270-272. doi: 10.1158/2643-3230.BCD-22-0046.
Abstract
Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations.
摘要
骨髓增生异常综合征 (MDS) 是一组由突变血细胞克隆性扩增引起的血液疾病，可进展为继发性急性髓系白血病 (sAML)。两项新的研究使用单细胞和深度测序来阐明 MDS 向 AML 的进展，揭示了离散的克隆结构和信号突变的驱动作用。
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本文引用的文献
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Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.信号基因突变的趋同克隆进化是骨髓增生异常综合征进展的标志。
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Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia.不同的克隆进化模式驱动骨髓增生异常综合征向继发性急性髓系白血病进展。
Blood Cancer Discov. 2022 Jul 6;3(4):316-329. doi: 10.1158/2643-3230.BCD-21-0128.
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