西班牙裔族群在出生特征、产妇出生地和早发性霍奇金淋巴瘤风险方面的差异：一项基于人群的病例对照研究。

Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birthplace, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case-Control Study.

机构信息

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

Department of Epidemiology, School of Public Health, University of California, Berkeley, California.

出版信息

Cancer Epidemiol Biomarkers Prev. 2022 Sep 2;31(9):1788-1795. doi: 10.1158/1055-9965.EPI-22-0335.

DOI:10.1158/1055-9965.EPI-22-0335

PMID:35709749

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9444874/

Abstract

BACKGROUND

Hispanic ethnicity differences in the risk of early-onset Hodgkin lymphoma diagnosed at <40 years are understudied. We conducted a population-based case-control study to evaluate associations between birth characteristics and early-onset Hodgkin lymphoma with a focus on potential ethnic differences.

METHODS

This study included 1,651 non-Hispanic White and 1,168 Hispanic cases with Hodgkin lymphoma endorsing a range of races diagnosed at the age of 0 to 37 years during 1988-2015 and 140,950 controls without cancer matched on race/ethnicity and year of birth from the California Linkage Study of Early-Onset Cancers. OR and 95% confidence intervals (CI) were estimated from multivariable logistic regression models.

RESULTS

Having a foreign-born mother versus a United States-born mother (i.e., the reference group) was associated with an increased risk of early-onset Hodgkin lymphoma among non-Hispanic Whites (OR = 1.52; 95% CI, 1.31-1.76; P < 0.01) and a decreased risk among Hispanics (OR = 0.78; 95% CI, 0.69-0.88; P < 0.01). Among both race groups, risk of early-onset Hodgkin lymphoma increased with birthweight and maternal age (all Ptrends < 0.01). Among non-Hispanic Whites, each 5-year increase in maternal age (OR = 1.11; 95% CI, 1.04-1.18; Ptrend < 0.01) and paternal age (OR = 1.07; 95% CI, 1.02-1.13; Ptrend < 0.01) was associated with increased risk of early-onset Hodgkin lymphoma. Compared with female Hispanics, male Hispanics had an increased risk of early-onset Hodgkin lymphoma (OR = 1.26; 95% CI, 1.12-1.42; P < 0.01).

CONCLUSIONS

Maternal birthplace may play a role in risk of early-onset Hodgkin lymphoma that differs by ethnicity.

IMPACT

The ethnic differences observed between certain birth characteristics, maternal birthplace, and early-onset Hodgkin lymphoma raise questions about the underlying biological, generational, lifestyle, residential, and genetic contributions to the disease.

摘要

背景

在 40 岁以下被诊断为早发性霍奇金淋巴瘤的西班牙裔人群中，其发病风险的种族差异尚未得到充分研究。我们开展了一项基于人群的病例对照研究，旨在评估出生特征与早发性霍奇金淋巴瘤之间的关联，并特别关注潜在的种族差异。

方法

本研究纳入了在 1988 年至 2015 年期间诊断为 0 岁至 37 岁的非西班牙裔白人 1651 例和西班牙裔 1168 例早发性霍奇金淋巴瘤病例，以及来自加利福尼亚早期癌症关联研究的 140950 例无癌症匹配的同种族/族裔和出生年份的对照者。多变量逻辑回归模型用于估计比值比（OR）和 95%置信区间（CI）。

结果

与美国出生的母亲（即参照组）相比，外国出生的母亲与非西班牙裔白人早发性霍奇金淋巴瘤风险增加相关（OR=1.52；95%CI，1.31-1.76；P <0.01），而与西班牙裔风险降低相关（OR=0.78；95%CI，0.69-0.88；P <0.01）。在这两个种族群体中，早发性霍奇金淋巴瘤的风险均随出生体重和母亲年龄的增加而升高（均 P <0.01）。在非西班牙裔白人中，母亲年龄每增加 5 岁（OR=1.11；95%CI，1.04-1.18；Ptrend <0.01）和父亲年龄每增加 5 岁（OR=1.07；95%CI，1.02-1.13；Ptrend <0.01）与早发性霍奇金淋巴瘤风险增加相关。与女性西班牙裔相比，男性西班牙裔早发性霍奇金淋巴瘤风险增加（OR=1.26；95%CI，1.12-1.42；P <0.01）。