College of Teacher Education, Zhejiang Normal University, Jinhua, China; Key Laboratory of Intelligent Education Technology and Application, Zhejiang Normal University, Jinhua, China.
School of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
J Affect Disord. 2022 Sep 1;312:69-77. doi: 10.1016/j.jad.2022.06.011. Epub 2022 Jun 13.
Autism spectrum disorder (ASD) is associated with altered brain connectivity. Previous studies have focused on the static functional connectivity pattern from amygdala subregions in ASD while ignoring its dynamics. Considering that dynamic functional connectivity (dFC) can provide different perspectives, the present study aims to investigate the dFC pattern of the amygdala subregions in ASD patients.
Data of 618 ASD patients and 836 typical controls (TCs) of 30 sites were obtained from the Autism Brain Imaging Data Exchange (ABIDE) database. The sliding window approach was applied to conduct seed-based dFC analysis. The seed regions were bilateral basolateral (BLA) and centromedial-superficial amygdala (CSA). A two-sample t-test was done at each site. Image-based meta-analysis (IBMA) based on the results from all sites was performed. Correlation analysis was conducted between the dFC values and the clinical scores.
The ASD patients showed lower dFC between the left BLA and the bilateral inferior temporal (ITG)/left superior frontal gyrus, between the right BLA and right ITG/right thalamus/left superior temporal gyrus, and between the right CSA and middle temporal gyrus. The ASD patients showed higher dFC between the left BLA and temporal lobe/right supramarginal gyrus, between the right BLA and left calcarine gyrus, and between the left CSA and left calcarine gyrus. Correlation analysis revealed that the symptom severity was positively correlated with the dFC between the bilateral BLA and ITG in ASD.
Abnormal dFC of the specific amygdala subregions may provide new insights into the pathological mechanisms of ASD.
自闭症谱系障碍（ASD）与大脑连接改变有关。以前的研究集中于 ASD 患者杏仁核亚区的静态功能连接模式，而忽略了其动态变化。考虑到动态功能连接（dFC）可以提供不同的视角，本研究旨在探讨 ASD 患者杏仁核亚区的 dFC 模式。
从自闭症脑成像数据交换（ABIDE）数据库中获取了 30 个地点的 618 名 ASD 患者和 836 名典型对照（TCs）的数据。采用滑动窗口方法进行基于种子的 dFC 分析。种子区域为双侧基底外侧（BLA）和中央-内侧-浅层杏仁核（CSA）。在每个部位进行双样本 t 检验。基于所有部位的结果进行基于图像的荟萃分析（IBMA）。对 dFC 值与临床评分进行相关性分析。
与 TCs 相比，ASD 患者左侧 BLA 与双侧颞下回（ITG）/左侧额上回、右侧 BLA 与右侧 ITG/右侧丘脑/左侧颞上回、右侧 CSA 与中颞回之间的 dFC 降低，左侧 BLA 与颞叶/右侧缘上回、右侧 BLA 与左侧楔前回、左侧 CSA 与左侧楔前回之间的 dFC 升高。相关性分析显示，ASD 患者双侧 BLA 与 ITG 之间的 dFC 与症状严重程度呈正相关。
特定杏仁核亚区的异常 dFC 可能为 ASD 的病理机制提供新的见解。
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