Giacometti C, Amiez C, Hadj-Bouziane F
Univ Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 69500, Bron, France.
Integrative Multisensory Perception Action & Cognition Team (ImpAct), INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center (CRNL), University of Lyon 1, Lyon, France.
Curr Res Neurobiol. 2023 Jul 28;5:100103. doi: 10.1016/j.crneur.2023.100103. eCollection 2023.
The network formed by the amygdala (AMG) and the medial Prefrontal Cortex (mPFC), at the interface between our internal and external environment, has been shown to support some important aspects of behavioral adaptation. Whether and how the anatomo-functional organization of this network evolved across primates remains unclear. Here, we compared AMG nuclei morphological characteristics and their functional connectivity with the mPFC in humans and macaques to identify potential homologies and differences between these species. Based on selected studies, we highlight two subsystems within the AMG-mPFC circuits, likely involved in distinct temporal dynamics of integration during behavioral adaptation. We also show that whereas the mPFC displays a large expansion but a preserved intrinsic anatomo-functional organization, the AMG displays a volume reduction and morphological changes related to specific nuclei. We discuss potential commonalities and differences in the dialogue between AMG nuclei and mPFC in humans and macaques based on available data.
杏仁核（AMG）和内侧前额叶皮质（mPFC）在我们的内部和外部环境之间的界面处形成的网络，已被证明支持行为适应的一些重要方面。该网络的解剖功能组织是否以及如何在灵长类动物中进化仍不清楚。在这里，我们比较了人类和猕猴中AMG核的形态特征及其与mPFC的功能连接，以确定这些物种之间潜在的同源性和差异。基于选定的研究，我们强调了AMG-mPFC回路中的两个子系统，它们可能参与行为适应过程中不同的时间整合动态。我们还表明，虽然mPFC显示出大规模扩张但保留了内在的解剖功能组织，而AMG则显示出体积减小和与特定核相关的形态变化。我们根据现有数据讨论了人类和猕猴中AMG核与mPFC之间对话中潜在的共性和差异。
