Yuan Liu, Wang Yangshuo, Cheng Shuhua, Zhang Junchen, Zhang Shaohui, Liu Tinghong, Zhang Guojun, Liang Shuli
Functional Neurosurgery Department, National Children's Health Center of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing, China.
Front Neurol. 2022 May 31;13:868633. doi: 10.3389/fneur.2022.868633. eCollection 2022.
To analyze the interictal discharge (IID) patterns on pre-operative scalp electroencephalogram (EEG) and compare the changes in IID patterns after removal of epileptogenic tubers in preschool children with tuberous sclerosis complex (TSC)-related epilepsy.
Thirty-five preschool children who underwent resective surgery for TSC-related epilepsy were enrolled retrospectively, and their EEG data collected before surgery to 3 years after surgery were analyzed.
Twenty-three (65.7%) patients were seizure-free post-operatively at 1-year follow-up, and 37-40% of post-operative patients rendered non-IID on scalp EEGs, and patients with focal IIDs or generalized IID patterns on pre-operative EEG presented a high percentage of normal post-operative scalp EEGs. IID patterns on pre-operative scalp EEGs did not influence the outcomes of post-operative seizure controls, while patients with non-IID and focal IID on post-operative EEGs were likely to achieve post-operative seizure freedom. Patients with new focal IIDs presented a significantly lower percentage of seizure freedom than those without new focal IIDs on post-operative EEGs at 3-year follow-up.
Over 1/3 children with TSC presented normal scalp EEGs after resective epileptsy surgery. Patients with post-operative seizure freedom were more likely to have non-IIDs on post-operative EEGs. New focal IIDs were negative factors for seizure freedom at the 3-year follow-up.
分析术前头皮脑电图（EEG）的发作间期放电（IID）模式，并比较结节性硬化症（TSC）相关癫痫的学龄前儿童切除致痫结节后IID模式的变化。
回顾性纳入35例接受TSC相关癫痫切除手术的学龄前儿童，并分析其术前至术后3年收集的EEG数据。
23例（65.7%）患者在术后1年随访时无癫痫发作，37%-40%的术后患者头皮EEG显示无IID，术前EEG有局灶性IID或全身性IID模式的患者术后头皮EEG正常的比例较高。术前头皮EEG的IID模式不影响术后癫痫控制的结果，而术后EEG无IID和局灶性IID的患者更有可能实现术后无癫痫发作。在3年随访时，术后EEG出现新的局灶性IID的患者无癫痫发作的比例明显低于无新局灶性IID的患者。
超过1/3的TSC患儿在切除性癫痫手术后头皮EEG正常。术后无癫痫发作的患者术后EEG更有可能无IID。新的局灶性IID是3年随访时无癫痫发作的负面因素。
