Yan Yu-Qin, Liu Lin, Sun Shuo, Feng Ying-Qing, Li Jie, Huang Yu-Qing
Department of Cardiology, People's Hospital of Shenzhen Baoan District, Shenzhen, China.
Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Front Nutr. 2022 May 31;9:898932. doi: 10.3389/fnut.2022.898932. eCollection 2022.
Although the evidence was still limited, some studies suggested that childhood malnutrition might affect cardiac function and structure in adulthood. To address the knowledge gap, this study investigated if the Great Chinese Famine exposure during early life had affected left ventricular hypertrophy (LVH).
This research was a cross-sectional study. It included participants who had cardiac ultrasound assessments and were born in Guangdong, China, from 1 October 1952 to 30 September 1964. They were classified according to their exposure period to famine, namely, no exposure, fetal-, early-, mid-, and late childhood. Multivariate logistic regression and subgroup analysis have been conducted to determine the odds ratio () and confidence intervals (s) between famine exposure and LVH.
This research included 2,543 participants, 1,612 women, their mean age was 59.07 ± 3.65 years, and 704 participants had LVH. LVH prevalence was 122 (23.6%), 87 (25.1%), 133 (27.3%), 184 (29.2%), and 178 (31.7%), in non-, fetal-, early-, mid-, and late-childhood exposed groups, respectively ( = 0.031), while in the non-exposed group, the s for developing carotid plaque as a result of fetal, early-, mid- to late-childhood exposure were 1.08 (95% : 0.76, 1.59, = 0.619), 1.24 (95% : 1.03, 1.79, = 0.031), 1.49 (95% : 1.10, 2.01, = 0.009), and 1.64 (95% : 1.25, 2.18, = 0.001), respectively ( for trend = 0.003). There was no interactive effect between gender, obesity, or hypertension history with how the famine influenced LVH, as the subgroups analyses demonstrated (all for interaction > 0.05).
This research has demonstrated the potential relationship between Great Chinese Famine exposure during childhood and LVH in adults.
尽管证据仍然有限，但一些研究表明儿童期营养不良可能会影响成年后的心脏功能和结构。为了填补这一知识空白，本研究调查了生命早期经历中国大饥荒是否会影响左心室肥厚（LVH）。
本研究为横断面研究。研究对象为1952年10月1日至1964年9月30日在中国广东出生且接受过心脏超声评估的参与者。根据他们暴露于饥荒的时期进行分类，即未暴露、胎儿期、幼儿期、童年中期和童年后期。进行了多因素逻辑回归和亚组分析，以确定饥荒暴露与左心室肥厚之间的优势比（OR）和置信区间（CI）。
本研究纳入2543名参与者，其中女性1612名，平均年龄为59.07±3.65岁，704名参与者患有左心室肥厚。在未暴露、胎儿期暴露、幼儿期暴露、童年中期暴露和童年后期暴露组中，左心室肥厚患病率分别为122例（23.6%）、87例（25.1%）、133例（27.3%）、184例（29.2%）和178例（31.7%）（P=0.031），而在未暴露组中，因胎儿期、幼儿期、童年中期至后期暴露而发生颈动脉斑块的OR分别为1.08（95%CI：0.76，1.59，P=0.619）、1.24（95%CI：1.03，1.79，P=0.031）、1.49（95%CI：1.10，2.01，P=0.009）和1.64（95%CI：1.25，2.18，P=0.001）（趋势P=0.003）。亚组分析表明，性别、肥胖或高血压病史与饥荒对左心室肥厚的影响之间没有交互作用（所有交互作用P>0.05）。
本研究证明了儿童期经历中国大饥荒与成年后左心室肥厚之间的潜在关系。
