Huang Yin, Chen Bo, Cao Dehong, Chen Zeyu, Li Jin, Guo Jianbing, Dong Qiang, Wei Qiang, Liu Liangren
Department of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, China.
West China School of Medicine, Sichuan University, Chengdu, China.
Front Med (Lausanne). 2022 May 31;9:816012. doi: 10.3389/fmed.2022.816012. eCollection 2022.
To report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.
From 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidemiological parameters, clinical characteristics, tumor markers, therapy, and follow-up data.
The median age of the patients was 28 years (range, 13-80 years). Para-aortic lymph node metastases were detected in 2 patients after radiological evaluation. Orchiectomy was performed in all patients, and the median diameter of the tumor was 1.5 cm (range, 0.5-5.0 cm). Nine Leydig cell tumors (LCTs), 5 Sertoli cell tumors (SCTs), and 1 unclassified type were confirmed after pathologic evaluation. Thirteen patients (86.7%) were categorized as stage I, and 2 patients (13.3%) were categorized as stage II. The median clinical follow-up was 39.0 months (range, 5-97 months), which showed 10 alive patients, such as 1 patient with progression at 40 months after orchiectomy. The 3- and 5-year progression-free survivals were 100 and 90.0%, respectively.
Testicular sex cord-stromal tumor at stages I and II is a rare subtype with benign behavior and a favorable prognosis in the Chinese population. However, lymph node metastases may be the dominant risk factor for patients with TSCST.
报告中国人群中首例伴有详细临床病理特征及长期随访结果的睾丸性索间质肿瘤（TSCST）系列病例。
2008年至2018年，本研究纳入了15例TSCST患者。对这些肿瘤的流行病学参数、临床特征、肿瘤标志物、治疗方法及随访数据进行分析。
患者的中位年龄为28岁（范围13 - 80岁）。经影像学评估，2例患者发现主动脉旁淋巴结转移。所有患者均接受了睾丸切除术，肿瘤的中位直径为1.5 cm（范围0.5 - 5.0 cm）。病理评估后确诊9例为睾丸间质细胞瘤（LCT），5例为支持细胞瘤（SCT），1例为未分类类型。13例患者（86.7%）被归类为I期，2例患者（13.3%）被归类为II期。中位临床随访时间为39.0个月（范围5 - 97个月），结果显示10例患者存活，例如1例患者在睾丸切除术后40个月出现病情进展。3年和5年无进展生存率分别为100%和90.0%。
I期和II期睾丸性索间质肿瘤在中国人群中是一种罕见的亚型，具有良性行为和良好的预后。然而，淋巴结转移可能是TSCST患者的主要危险因素。
