Université de Lyon, UJM-Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité, Saint-Etienne, France.
SIGVARIS SAS, St-Just St-Rambert Cedex, France.
J Vasc Surg Venous Lymphat Disord. 2022 Sep;10(5):1147-1154.e1. doi: 10.1016/j.jvsv.2022.04.016. Epub 2022 Jun 15.
The aim of this study was to quantify fatigue and quality of life (QoL) in people self-reporting chronic venous disease (CVD) symptoms or at risk of CVD within a large cohort representative of the French population. The relationship between self-reported physical activity and both fatigue and QoL was also investigated. We hypothesized that a greater fatigue and impaired QoL would exist in participants self-reporting CVD symptoms, with the impairments being attenuated in those with greater level of physical activity.
Using a web-based, custom and adaptive survey, 3008 participants were asked to self-report the presence of common symptoms and risk factors of CVD. Fatigue, QoL, and physical activity were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue scale, the Chronic Venous Insufficiency Quality of Life Questionnaire, and the Godin-Shepard Leisure-Time Physical Activity Questionnaire, respectively.
Thirty-two percent of participants were categorized as having CVD symptoms, whereas 50% were categorized as at risk of CVD. Fatigue was greater in participants with CVD symptoms than non-CVD participants (P < .001), with the score of participants at risk of CVD being intermediate (P ≤ .001). QoL was more impaired in participants with CVD symptoms compared with participants at risk of CVD (P < .001). In participants with CVD symptoms, there were relationships between fatigue and QoL (P < .001) and between physical activity and fatigue (P < .001). Despite the relationship between physical activity and QoL not reaching significance (P = .067), a lower QoL was found in insufficiently active as compared with active (P < .001) and moderately active (P < .001) participants with CVD symptoms.
Participants self-reporting CVD symptoms suffer from greater fatigue and impaired QoL. In this population, a higher level of physical activity is associated with less fatigue and a tendency toward improved QoL.
本研究旨在量化报告患有慢性静脉疾病（CVD）症状或有 CVD 风险的人群的疲劳和生活质量（QoL），并对报告患有 CVD 症状的人群中，自我报告的体力活动与疲劳和 QoL 的关系进行研究。我们假设报告患有 CVD 症状的参与者会出现更大的疲劳和受损的 QoL，而体力活动水平较高的参与者，其损伤程度会减轻。
通过基于网络的、定制和自适应调查，要求 3008 名参与者报告常见 CVD 症状和危险因素。使用慢性疾病治疗疲劳功能评估量表、慢性静脉功能不全生活质量问卷和 Godin-Shepard 休闲时间体力活动问卷分别评估疲劳、QoL 和体力活动。
32%的参与者被归类为患有 CVD 症状，而 50%的参与者被归类为有 CVD 风险。与非 CVD 参与者相比，有 CVD 症状的参与者疲劳程度更大（P<0.001），有 CVD 风险的参与者的得分则处于中间水平（P≤0.001）。与有 CVD 风险的参与者相比，有 CVD 症状的参与者的 QoL 受损更为严重（P<0.001）。在有 CVD 症状的参与者中，疲劳与 QoL 之间存在相关性（P<0.001），体力活动与疲劳之间也存在相关性（P<0.001）。尽管体力活动与 QoL 之间的关系未达到显著水平（P=0.067），但与有 CVD 症状的不活跃、活跃和适度活跃参与者相比，不活跃参与者的 QoL 较低（P<0.001）。
报告患有 CVD 症状的参与者会出现更大的疲劳和受损的 QoL。在该人群中，较高的体力活动水平与较低的疲劳和改善 QoL 的趋势相关。
