Department of Cardiovascular Sciences, University of South Florida Morsani College of Medicine, South Tampa Center (3rd Floor), Tampa, FL 33606, USA; Tampa General Hospital, 1 Tampa General Circle, Tampa, FL 33606, USA.
Department of Cardiovascular Sciences, University of South Florida Morsani College of Medicine, South Tampa Center (3rd Floor), Tampa, FL 33606, USA; Tampa General Hospital, 1 Tampa General Circle, Tampa, FL 33606, USA.
Card Electrophysiol Clin. 2022 Jun;14(2):297-310. doi: 10.1016/j.ccep.2021.12.005. Epub 2022 May 25.
Although conventional biventricular pacing has been shown to benefit patients with heart failure and conduction system disease, there are limitations to its therapeutic success, resulting in widely variable clinical response. Limitations of conventional biventricular pacing evolve around myocardial scar, fibrosis, and inability to effectively stimulate diseased tissue. Several observational and acute hemodynamic studies have demonstrated improved electrical resynchronization and echocardiographic response with conduction system pacing. This article provides a systematic review of conduction system pacing as a physiologic alternative to conventional CRT, which is currently undergoing rigorous investigation.
尽管传统的双心室起搏已被证明对心力衰竭和传导系统疾病患者有益，但它的治疗效果存在局限性，导致临床反应差异很大。传统双心室起搏的局限性在于心肌瘢痕、纤维化以及无法有效地刺激病变组织。几项观察性和急性血液动力学研究表明，通过传导系统起搏可改善电同步和超声心动图反应。本文对传导系统起搏作为传统 CRT 的生理性替代方法进行了系统评价，目前正在进行严格的研究。
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