Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 38 Gheorghe Marinescu Street, Targu Mures 540139, Romania.
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA.
Surg Pathol Clin. 2022 Jun;15(2):369-388. doi: 10.1016/j.path.2022.02.010.
Squamous cell carcinoma is the most frequent epithelial malignant tumor of the cervix and among the most frequent neoplasm in women worldwide. Endocervical adenocarcinoma is the second most common malignancy. Both tumors and their precursors are currently classified based on human papillomavirus status, with prognostic and predictive value. Various prognostic biomarkers and alternative morphologic parameters have been recently described and could be used in the management of these patients. This pragmatical review highlights recent developments, emerging issues as well as controversial areas regarding the cause-based classification, diagnosis, staging, and prognostic parameters of epithelial malignant tumors of the cervix.
鳞状细胞癌是宫颈最常见的上皮恶性肿瘤，也是全球女性最常见的肿瘤之一。宫颈内膜腺癌是第二常见的恶性肿瘤。目前，这两种肿瘤及其前体均基于人乳头瘤病毒状态进行分类，具有预后和预测价值。最近还描述了各种预后生物标志物和替代形态参数，可用于这些患者的治疗。本实用综述强调了宫颈上皮恶性肿瘤基于病因的分类、诊断、分期和预后参数方面的最新进展、新出现的问题和有争议的领域。
