Department of Drug Science and Health, University of Catania, Via S. Sofia, 64, 95125 Catania, Italy.
Department of Chemical Science, University of Catania, Via S. Sofia, 64, 95125 Catania, Italy.
Colloids Surf B Biointerfaces. 2022 Sep;217:112628. doi: 10.1016/j.colsurfb.2022.112628. Epub 2022 Jun 14.
Core-shell nanocomposites are one of the most important achievements in the fast-growing field of nanotechnology. The combination of multi-responsive nano-shell with luminescent and photothermal core has led to promising applications in various fields such as optics, electronics and medicine. In this work, a nanosized core-shell system composed by carbonized dots core and poly(N-isopropylacrylamide) shell was developed and the photothermal triggered release of doxorubicin was demonstrated. The system was fully characterized by H-NMR, DLS, Z-potential, AFM, optical absorption and fluorescence measurements. A photothermal conversion efficiency (η) value of about 67.9% and a doxorubicin photo-release rate value of about 1.0% min were measured. Molecular dynamic (MD) simulations data were in agreement with experimental results, at 310 K the coil-to-globule transition and a consequent desorption of doxorubicin from the polymer were observed. Both the radius of gyration and the fluctuation of the distance doxorubicin-PNIPAM pointed that the temperature above the LCST and the acid pH facilitated the polymer transition. Moreover, MD simulations and experimental data suggested an influence on the lower critical solution temperature (LCST) exerted by the number of polymer chains anchored to the carbon core.
核壳纳米复合材料是快速发展的纳米技术领域的重要成果之一。多功能响应性纳米壳与发光和光热核的结合，导致了在光学、电子学和医学等各个领域有前景的应用。在这项工作中，开发了一种由碳化点核和聚（N-异丙基丙烯酰胺）壳组成的纳米级核壳系统，并证明了阿霉素的光热触发释放。该系统通过 H-NMR、DLS、Z-电位、AFM、光吸收和荧光测量进行了全面表征。测量得到的光热转换效率（η）值约为 67.9%，阿霉素的光释放率约为 1.0% min。分子动力学（MD）模拟数据与实验结果一致，在 310 K 下观察到从聚合物中解吸的构象转变和随之而来的阿霉素解吸。均方根回转半径和 doxorubicin-PNIPAM 之间的距离波动都表明，LCST 以上的温度和酸性 pH 值有利于聚合物的转变。此外，MD 模拟和实验数据表明，与碳核结合的聚合物链的数量对临界溶解温度（LCST）有影响。
