Erciyes University , Faculty of Dentistry Department of Oral and Maxillofacial Surgery 38039 Kayseri, Turkey
Med Oral Patol Oral Cir Bucal. 2022 Jul 1;27(4):e357-e365. doi: 10.4317/medoral.25280.
The aim of the study was to evaluate the changes in craniofacial dimensions of newly diagnosed and untreated acromegaly patients, patients with non-functional pituitary adenoma and healthy individuals on Cone Beam Computed Tomography (CBCT).
50 newly diagnosed acromegaly patients who did not receive any treatment for acromegaly were included in the study (Group A). Twenty patients with nonfunctional pituitary adenoma (Group B) and 30 healthy individuals were included (Group C). Linear, angular and volumetric measurements were performed.
Mandibular length showed significant difference in acromegaly patients, and maxillar length statistically significant difference was found between the A-B and B-C (p> 0,05), no difference was found between the A-C (p<0,05). SNB and ANB angle was statistically different in all groups, while SNA angle was statistically different between group A-C and B-C. In volumetric measurements, a statistically significant difference was found between groups a-c and groups A-B (p< 0,05), no difference was found between groups B-C (p>0,05).
CBCT measurements showed that mandibular volume and length were increased in the acromegaly group compared to the group B-C. Present study is the first research that compares acromegaly patients in respect to changes in maxillofacial dimensions.
本研究旨在通过锥形束 CT（CBCT）评估新诊断且未经治疗的肢端肥大症患者、无功能性垂体腺瘤患者和健康个体的颅面维度的变化。
本研究纳入了 50 名新诊断的肢端肥大症患者（未接受肢端肥大症治疗）（A 组）。纳入 20 名无功能性垂体腺瘤患者（B 组）和 30 名健康个体作为对照组（C 组）。进行了线性、角度和体积测量。
肢端肥大症患者的下颌长度存在显著差异，A 组和 B 组之间的上颌长度存在统计学显著差异（p>0.05），而 A 组和 C 组之间无差异（p<0.05）。所有组的 SNB 和 ANB 角均存在统计学差异，而 A 组和 C 组、B 组和 C 组之间的 SNA 角存在统计学差异。在体积测量方面，A 组、B 组和 C 组之间存在统计学差异，而 B 组和 C 组之间无差异（p<0.05）。
CBCT 测量结果显示，与 B 组相比，肢端肥大症组的下颌体积和长度增加。本研究是首次比较肢端肥大症患者的颌面维度变化的研究。
